6939-35-1

Usage

Uses

Used in Pharmaceutical and Medicinal Chemistry:
5-Methoxy-1-Tetralone is used as a chemical intermediate for the synthesis of various pharmaceutical and medicinal compounds. Its unique structure and reactivity make it a valuable component in the development of new drugs and therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 5-Methoxy-1-Tetralone serves as a key intermediate for the preparation of a wide range of organic compounds. Its versatility in undergoing various chemical reactions allows for the creation of diverse molecules with potential applications in different industries.
Used in Research and Development:
5-Methoxy-1-Tetralone is utilized in research and development settings to explore its potential applications and properties. Scientists and researchers investigate its reactivity, stability, and interactions with other compounds to gain insights into its possible uses and benefits.
Used in Chemical Manufacturing:
In the chemical manufacturing industry, 5-Methoxy-1-Tetralone is employed as a raw material or intermediate in the production of various chemical products. Its high reactivity and unique structure contribute to the development of innovative and specialized chemicals for different applications.
Used in Analytical Chemistry:
5-Methoxy-1-Tetralone is also used in analytical chemistry for the identification, quantification, and characterization of compounds. Its distinct properties and reactivity make it a useful tool in analytical techniques such as chromatography, spectroscopy, and mass spectrometry.

InChI:InChI=1/C11H12O/c1-8-4-2-6-10-9(8)5-3-7-11(10)12/h2,4,6H,3,5,7H2,1H3

Upstream product

• 6943-79-9 4-(2-methylphenyl)butanoic acid 
• 859809-70-4 4-o-tolyl-butyryl chloride 
• 104665-67-0 4-(2-carboxy-6-methyl-phenyl)-butyric acid 
• 2809-64-5 5-methyltetralin 
• 77970-22-0 5-Methyl-3,4,5,8-tetrahydro-2H-naphthalen-1-one 
• 7664-93-9 sulfuric acid 
• 7446-70-0 aluminium trichloride 
• 855220-15-4 4-(4-tert-butyl-2-methyl-phenyl)-butyryl chloride 
• 71-43-2 benzene 
• 14902-36-4 3-(2-methylphenyl)-1-propanol 
• 21851-78-5 1-(3-bromopropyl)-2-methylbenzene 
• 23203-13-6 1-methyl-2-chloromethyl-4-(1,1-dimethylethyl)benzene 
• 4373-24-4 5-methyl-1,4-dihydro-naphthalene 
• 62164-86-7 4-(m-tolyl)but-3-enoic acid 

Downstream Products

• 858439-60-8 8-methyl-4-phenethyl-1,2-dihydro-naphthalene 
• 571-61-9 1,5-dimethylnaphthalene 
• 858199-17-4 8-methyl-4-phenyl-1,2-dihydro-naphthalene 
• 23203-37-4 5-methyl-3,4-dihydro-2H-naphthalen-1-one semicarbazone 
• 23203-36-3 5-methyl-3,4-dihydro-2H-naphthalen-1-one-(2,4-dinitro-phenylhydrazone) 
• 1612867-50-1 (2Z,4E)-4-[5'-methyl-3′,4′-dihydro-1′(2′H)-naphthalen-1′-ylidene]-3-methyl-2-butenoic acid 
• 6337-29-7 3-(4-hydroxy-5,6-dihydro-4H-phenalen-1-yl)-propionic acid 
• 861093-83-6 1-methyl-5-phenethyl-naphthalene 
• 192987-41-0 4-[1-(1-hydroxy-5-methyl-1,2,3,4-tetrahydronaphthyl)]-N-(triphenylmethyl)imidazole 
• 23702-40-1 1-Oxo-5-methyl-2-(2-isobutyryl-cyclohexyl)-tetralin 

Relevant academic research and scientific papers

Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light

An intramolecular arene alkylation reaction has been developed using the organic photocatalyst 4CzIPN, visible light, and N-(acyloxy)phthalimides as radical precursors. Reaction conditions were optimized via high-throughput experimentation, and electron-rich and electron-deficient arenes and heteroarenes are viable reaction substrates. This reaction enables access to a diverse set of fused, partially saturated cores which are of high interest in synthetic and medicinal chemistry.

Highly enantioselective [3+2] coupling of cyclic enamides with quinone monoimines promoted by a chiral phosphoric acid

Enantioselective [3+2] coupling of cyclic enamides with quinone monoimines was realised using a chiral phosphoric acid as a catalyst. This transformation allowed for the synthesis of highly enantioenriched polycyclic 2,3-dihydrobenzofurans (up to 99.9% ee). The absolute configuration of one product was determined by an X-ray crystal structural analysis. We also found a possible mechanism for this reaction.

Enantioselective halogenative semi-pinacol rearrangement: Extension of substrate scope and mechanistic investigations

The present Full Paper article discloses a survey of our recent results obtained in the context of the enantioselective halogenation-initiated semi-pinacol rearrangement. Commencing with the fluorination/semi-pinacol reaction first and moving to the heavier halogens (bromine and iodine) second, the scope and limitations of the halogenative phase-transfer methodology will be discussed and compared. An extension of the fluorination/semi-pinacol reaction to the ring-expansion of five-membered allylic cyclopentanols will be also described, as well as some preliminary results on substrates prone to desymmetrization will be given. Finally, the present manuscript will culminate with a detailed mechanistic investigation of the canonical fluorination/semi-pinacol reaction. Our mechanistic discussion will be based on in situ reaction progress monitoring, complemented with substituent effect, kinetic isotopic effect and non-linear behaviour studies.

Enantioselective organocatalytic fluorination-induced Wagner-Meerwein rearrangement

Cracked under strain: Strained allylic cyclobutanols and cyclopropanols readily undergo a ring expansion described by the title rearrangement. This reaction is promoted by catalytic amounts of 1 and displays high tolerance with respect to the substrate scope. The corresponding β-fluoro spiroketone products are isolated in high yields and with excellent stereoselectivities. EDG=electron-donating group, EWG=electron-withdrawing group. Copyright

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

Medetomidine analogs as α2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with α2-adrenoceptors involving a 'methyl pocket'

The synthesis and the biological evaluation of a new series of medetomidine analogs are reported. The substitution pattern at the phenyl ring of the tetralin analogs had a distinct influence on the α2- adrenoceptor binding affinity. 4-Methylindan analog 6 was the most potent α2-adrenoceptor binding ligand among these 4-substituted imidazoles, and its α2-adrenoceptor selectivity was greater than the 5-methyl tetralin analog 4c. Ligand-pharmacophore and receptor modeling were combined to rationalize α2-adrenoceptor binding data of the imidazole analogs in terms of ligand-receptor interactions. The structure-activity relationships that were apparent from this and previous studies were qualitatively rationalized by the binding site models of the α2-adrenoceptor. The benzylic methyl group of medetomidine or the naphthyl analog 2a was superimposable with the α-methyl group of (-)-α-methylnorepinephrine and fit into the proposed 'methyl pocket' of the α2-adrenoceptor defined by the residues Leu110, Leu169, Phe391, and Thr395.

Hexa-cyclic compound

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: STR1 The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.

SCHWEFELVERBINDUNGEN DES ERDOELS XV. METHYL-5,6,7,8-TETRAHYDRODINAPHTHOTHIOPHENE UND METHYLDINAPHTHOTHIOPHENE

A one pot synthesis gives methyl-5,6,7,8-tetrahydrodinaphthothiophenes (7) from methyl-1,2,3,4-tetrahydronaphthalen-1-ones (1) by bromination and sulfurization.Tetrahydro compounds 7 have been dehydrogenated to corresponding dinaphthothiophenes 8.Proofs for the constitutions are nmr data of 7, 8 and the independent synthesis of one compound 8.A reaction mechanism with 1,4-dithiine intermediates is discussed. Key words: Alkyl-1,2,3,4-tetrahydronaphthalen-1-ones; alkyl-5,6,7,8-tetrahydrodinaphthothiophenes; alkyldinaphthothiophenes; dehydrogenation with o-chlorobenzoquinone.

Novel Synthesis of 5,5-Dimethyl-1-octalin Derivatives

Pyrolysis of 3-isopropenyl-2-allylcyclohex-2-en-1-one (4) at ca. 275 deg C yielded 3,4,5,6-tetrahydro-5,5-dimethyl-1(2H)-naphthalenone (1) as the chief product.Higher pyrolysis temperatures also yielded methyl substituted α-tetralones derived from 1.Reductive methylation of 1 gave the trans-angularly methylated derivative 9 as the only product.The dienolate intermediate in this transforamtion was also trapped as a trimethyl ether, 8.Mechanisms for the pyrolytic rearrangement and the reductive alkylation are discussed.