153758-56-6

Basic information

• Product Name: (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-METHANOL
• Synonyms: (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-METHANOL;1-Isoquinolinemethanol, 1,2,3,4-tetrahydro-;1,2,3,4-Tetrahydro-1-isoquinolinemethanol
• CAS NO: 153758-56-6
• Molecular Formula: C10H13NO
• Molecular Weight: 163.22
• Mol File: 153758-56-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 306.7°C at 760 mmHg
• Flash Point: 146°C
• Appearance: /
• Density: 1.081g/cm³
• Vapor Pressure: 0.00033mmHg at 25°C
• Refractive Index: 1.549
• PKA: 14.48±0.10(Predicted)
• CAS DataBase Reference: (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-METHANOL(153758-56-6)
• EPA Substance Registry System: (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-METHANOL(153758-56-6)

Safety Data

• Hazardous Substances Data: 153758-56-6(Hazardous Substances Data)

Usage

General Description

(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-methanol is a chemical compound with potential biomedical applications. It is a derivative of isoquinoline, a heterocyclic organic compound, and is characterized by a tetrahydroisoquinoline ring structure. The compound has been studied for its potential as a pharmaceutical intermediate, and it may have potential as a building block for the synthesis of various drugs and biologically active molecules. Its structure and properties make it a potential candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C10H13NO/c12-7-10-9-4-2-1-3-8(9)5-6-11-10/h1-4,10-12H,5-7H2

Upstream product

• 27311-63-3 1-Hydroxymethyl-isoquinoline 
• 41034-52-0 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 27104-72-9 methyl isoquinoline-1-carboxylate 
• 50458-78-1 ethyl isoquinoline-1-carboxylate 
• 486-73-7 1-isoquinolinecarboxylic acid 

Relevant articles and documents

Synthesis and biological activities of a novel class of azole-containing antifungal agents

A series of novel 1,2,3,4-tetrahydroisoquinoline derived azoles has been designed and synthesized as antifungal agents which might function as inhibitors of cytochrome P-450 dependent lanosterol 14α-demethylase. In vitro tests showed that some of these compounds, especially 5b and 6b, effectively inhibit the growth of several strains of yeasts as well as molds.

Discovery of Dihydropyrrolo[1,2- a]pyrazin-3(4 H)-one-Based Second-Generation GluN2C- And GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl- d -Aspartate (NMDA) Receptor

The N-methyl-d-aspartate receptor (NMDAR) is an ion channel that mediates the slow, Ca2+-permeable component of glutamatergic synaptic transmission in the central nervous system (CNS). NMDARs are known to play a significant role in basic neurological functions, and their dysfunction has been implicated in several CNS disorders. Herein, we report the discovery of second-generation GluN2C/D-selective NMDAR-positive allosteric modulators (PAMs) with a dihydropyrrolo[1,2-a]pyrazin-3(4H)-one core. The prototype, R-(+)-EU-1180-453, exhibits log unit improvements in the concentration needed to double receptor response, lipophilic efficiency, and aqueous solubility, and lowers cLogP by one log unit compared to the first-generation prototype CIQ. Additionally, R-(+)-EU-1180-453 was found to increase glutamate potency 2-fold, increase the response to maximally effective concentration of agonist 4-fold, and the racemate is brain-penetrant. These compounds are useful second-generation in vitro tools and a promising step toward in vivo tools for the study of positive modulation of GluN2C- and GluN2D-containing NMDA receptors.