41069-05-0

Basic information

• Product Name: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide
• Synonyms: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide
• CAS NO: 41069-05-0
• Molecular Weight: 354.773
• Mol File: 41069-05-0.mol

Chemical Properties

• CAS DataBase Reference: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide(41069-05-0)
• EPA Substance Registry System: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide(41069-05-0)

Safety Data

• Hazardous Substances Data: 41069-05-0(Hazardous Substances Data)

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 829-85-6 diphenylphosphane 
• 3240-10-6 (4-chlorophenyl)propiolic acid 
• 4559-70-0 Diphenylphosphine oxide 
• 108-86-1 bromobenzene 
• 873-73-4 4-n-chlorophenylacetylene 
• 1615-02-7 p-chlorocinnamic acid 
• 208118-80-3 1-(4-chlorophenyl)ethenylacetamide 
• 99-91-2 para-chloroacetophenone 
• 1956-39-4 4-chloroacetophenone oxime 
• 184849-67-0 1-(4-chlorophenyl)ethanone O-acetyl oxime 

Relevant articles and documents

Direct synthesis of β-ketophosphine oxides via copper-catalyzed difunctionalization of alkenes with H-phosphine oxides and dioxygen

A simple copper-catalyzed direct difunctionalization of alkenes with H-phosphine oxides and dioxygen for the synthesis of β-ketophosphine oxides has been developed under mild conditions. The present protocol, which utilizes an inexpensive catalyst, readily available materials, and environmentally benign oxygen source, provides a convenient and cost-effective approach to construct various β-ketophosphine oxides.

Silver-Catalyzed Oxyphosphorylation of Unactivated Alkynes

Here, we describe an application of hydroazidation in the instant activation of alkynes for achieving the oxyphosphorylation of unactivated alkynes with diarylphosphinoyl radicals under mild reaction conditions. This reaction provides a method for accessing β-ketophosphine oxides and phosphorus-containing pyrroles. (Figure presented.).

An efficient preparation of β-ketophosphine oxides from alkynylphosphine oxides with benzaldehyde oxime as a hydroxide source

An effective and facile transitio-metal-free method has been developed for the synthesis of β-ketophosphine oxides from alkynylphosphine oxides with benzaldehyde oxime as a hydroxide surrogate. The current methodology provides simple access to various β-ketophosphine oxides in moderate to excellent yields with a broad substrate scope.

Visible Light-Mediated Photocatalytic Metal-Free Cross-Coupling Reaction of Alkenyl Carboxylic Acids with Diarylphosphine Oxides Leading to β-Ketophosphine Oxides

A new visible light-mediated photocatalytic decarboxylative oxyphosphorylation of cinnamic acids with diarylphosphine oxides is described. This reaction is performed under mild conditions to afford the corresponding β-ketophosphine oxides.

Base-Promoted Direct Oxyphosphorylation of Alkynes with H-Phosphine Oxides in the Presence of Water

We have developed a simple method for the oxyphosphorylation of arylalkynes to give β-keto phosphine oxides without the assistance of any transition metal. An inorganic base promoted the oxyphosphorylation and water played a synergistic role in the formation of various β-keto phosphine oxides. The reaction showed a wide structural scope and broad functional-group tolerance, and it proceeded under mild reaction conditions. This method solved the problem of metal dependence in the oxyphosphorylation of alkynes, providing a potential application in organic chemistry. Control experiments revealed the mechanism of the oxyphosphorylation and the synergistic role played by water in the radical process.

Visible light-promoted metal-free aerobic oxyphosphorylation of olefins: A facile approach to β-ketophosphine oxides

A metal-free direct aerobic oxyphosphorylation of alkenes with H-phosphine oxides has been developed utilizing visible light photoredox catalysis. A variety of β-ketophosphine oxides have been obtained in good yields from simple olefins under air with ine

Copper-Catalyzed Direct Oxyphosphorylation of Enamides with P(O)-H Compounds and Dioxygen

A simple and convenient copper-catalyzed direct oxyphosphorylation of enamides with P(O)-H compounds and dioxygen has been developed under mild conditions. This methodology can allow the synthesis of a series of valuable β-ketophosphine oxides/β-ketophosphonates in moderate to good yields with a broad substrate scope simply by using readily-available starting materials.

Metal-free oxidative phosphinylation of aryl alkynes to β-ketophosphine oxides via visible-light photoredox catalysis

A method for photocatalytic oxidative coupling of diaryl phosphine oxide and arylacetylene under mild conditions was developed. Rhodamine B, an inexpensive and commercially available organic dye, was used as the photocatalyst. This protocol realizes a reg

Copper-catalyzed direct oxyphosphorylation of alkynes with H-phosphine oxides and dioxygen: A convenient approach to β-ketophosphine oxides

A simple and facile copper-catalyzed synthesis of β-ketophosphine oxides via direct oxyphosphorylation of alkynes with H-phosphine oxides and dioxygen has been developed under mild conditions without any base or cocatalyst. A radical reaction pathway for

Solvent-controlled direct radical oxyphosphorylation of styrenes mediated by Manganese(III)

Direct radical oxyphosphorylation of styrenes with diarylphosphine oxides and dialkyl phosphites mediated by Mn(OAc)3 is described. The solvent played a key role in this selective difunctionalization reaction.