41069-05-0

Basic information

• Product Name: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide
• Synonyms: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide
• CAS NO: 41069-05-0
• Molecular Weight: 354.773
• Mol File: 41069-05-0.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide(41069-05-0)
• EPA Substance Registry System: (2-oxo-2-(4-chlorophenyl)ethyl)diphenylphosphine oxide(41069-05-0)

Safety Data

• Hazardous Substances Data: 41069-05-0(Hazardous Substances Data)

Upstream product

• 184849-67-0 1-(4-chlorophenyl)ethanone O-acetyl oxime 
• 4559-70-0 Diphenylphosphine oxide 
• 1956-39-4 4-chloroacetophenone oxime 
• 99-91-2 para-chloroacetophenone 
• 108-86-1 bromobenzene 
• 1615-02-7 p-chlorocinnamic acid 
• 1073-67-2 4-vinylbenzyl chloride 
• 873-73-4 4-n-chlorophenylacetylene 
• 3240-10-6 (4-chlorophenyl)propiolic acid 
• 208118-80-3 1-(4-chlorophenyl)ethenylacetamide 
• 829-85-6 diphenylphosphane 

Relevant articles and documents

Direct synthesis of β-ketophosphine oxides via copper-catalyzed difunctionalization of alkenes with H-phosphine oxides and dioxygen

A simple copper-catalyzed direct difunctionalization of alkenes with H-phosphine oxides and dioxygen for the synthesis of β-ketophosphine oxides has been developed under mild conditions. The present protocol, which utilizes an inexpensive catalyst, readily available materials, and environmentally benign oxygen source, provides a convenient and cost-effective approach to construct various β-ketophosphine oxides.

An efficient preparation of β-ketophosphine oxides from alkynylphosphine oxides with benzaldehyde oxime as a hydroxide source

An effective and facile transitio-metal-free method has been developed for the synthesis of β-ketophosphine oxides from alkynylphosphine oxides with benzaldehyde oxime as a hydroxide surrogate. The current methodology provides simple access to various β-ketophosphine oxides in moderate to excellent yields with a broad substrate scope.

Base-Promoted Direct Oxyphosphorylation of Alkynes with H-Phosphine Oxides in the Presence of Water

We have developed a simple method for the oxyphosphorylation of arylalkynes to give β-keto phosphine oxides without the assistance of any transition metal. An inorganic base promoted the oxyphosphorylation and water played a synergistic role in the formation of various β-keto phosphine oxides. The reaction showed a wide structural scope and broad functional-group tolerance, and it proceeded under mild reaction conditions. This method solved the problem of metal dependence in the oxyphosphorylation of alkynes, providing a potential application in organic chemistry. Control experiments revealed the mechanism of the oxyphosphorylation and the synergistic role played by water in the radical process.