41104-54-5

Upstream product

• 100-52-7 benzaldehyde 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 2431-23-4 4-methylbenzoin 

Downstream Products

• 127029-79-2 2-morpholinyl-2-phenyl-1-(4-methylphenyl)-1-ethanone 
• 1189516-69-5 C₁₉H₁₇NO₃ 
• 69048-36-8 2-(4-Nitro-phenylsulfanyl)-2-phenyl-1-p-tolyl-ethanone 
• 69254-46-2 2-Phenyl-1-p-tolyl-2-p-tolylsulfanyl-ethanone 
• 73908-27-7 (1R,2S)-2-Chloro-2-phenyl-1-p-tolyl-ethanol 

Relevant academic research and scientific papers

Unusual redox behavior in the photoinduced electron-transfer reactions of amino ketones

Irradiation of a wet benzene solution of 1,2-diphenyl-2-piperidino-l-ethanone and 9,10-dicyanoanthracene leads to the formation of benzil and deoxybenzoin. We have interpreted these products as arising from deprotonation leading to net oxidation coupled with reductive elimination. The latter pathway is noteworthy in that we show reductive elimination of an electron donor can be a chief consequence of photochemical single electron transfer (SET) quenching.

Singlet oxygen mediated fragmentation of amino alcohols, 1,2-diamines, and amino ketones

Irradiation of aerated solutions of singlet oxygen sensitizers such as Rose Bengal, Rose Bengal derivative, or palladium tetraphenylporphyrin in the presence of substituted amines (amino alcohols, 1,2-diamines, and amino ketones) results in oxidative fragmentation of the amine in good chemical yield and with low-to-moderate quantum efficiency. For the amino alcohols and 1,2-diamines the reaction course is similar to that initiated by irradiation of electron-transfer "sensitizers" such as thioindigo or cyanoaromatics. In these cases the reaction has been shown to proceed via single electron transfer oxidation of the amine and subsequent cleavage of the amine cation radical. A similar mechanism is proposed for the reaction with singlet oxygen sensitizers in which singlet oxygen initiates reaction by SET oxidation of the amine donors and subsequent reaction from the resulting superoxide-amine cation ion radical pair. For reaction with amino ketones under the same conditions, irradiation results in formation of novel fragmentation products incorporating oxygen. Labeling studies with O-18 enriched oxygen indicate that air is the source of certain of the incorporated oxygen in the products and suggest a mechanism closely related to the other fragmentation processes.

Azole derivatives

Azole derivatives of the formula SPC1 Wherein R1 is free or esterified carboxyl or other functionally modified carboxyl group, R2 and R3 each are aryl; A is Cn H2n in which n is an integer from 1 to 10, inclusive; and Z is O or S; and the physiologically acceptable salts thereof, possess, with good compatibility, excellent antiphlogistic activity and, in particular, influence favorably the chronic progressive diseases of the joints, e.g., arthritis. They can be prepared from compounds of the formula SPC2 Wherein X1 is a group convertible into the group --S--A--R1, and R2 and R3 have the values given above.