41147-82-4

Usage

Uses

Used in Research Applications:
4-Bromo-beta-hydroxyphenethylamine is used as a research chemical for studying the effects and mechanisms of action of psychedelic drugs on the human brain, particularly their interaction with serotonin receptors. This helps in understanding the potential therapeutic applications and risks associated with these substances.
Used in Pharmaceutical Development:
Although its recreational use and legal restrictions limit its pharmaceutical applications, 4-Bromo-beta-hydroxyphenethylamine serves as a compound of interest in the development of new medications for various psychiatric and neurological disorders. Its structure and activity can provide insights into designing safer and more effective drugs targeting the serotonin system.
Used in Toxicological Studies:
4-Bromo-beta-hydroxyphenethylamine is used as a reference substance in toxicological research to evaluate the harmful effects of psychedelic drugs on human health. This helps in establishing safety guidelines and understanding the risks associated with the consumption of such substances.
Note: The uses mentioned above are for informational purposes only and do not endorse or promote the use of 4-Bromo-beta-hydroxyphenethylamine in any form, given its legal status and potential health risks.

Upstream product

• 49615-87-4 2-(4-bromophenyl)-2-oxoacetaldehyde oxime 
• 32017-76-8 (+/-)-2-(4-bromophenyl)oxirane 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 99-73-0 para-bromophenacyl bromide 
• 7644-04-4 4-bromophenacylamine 
• 5467-72-1 α-amino-4-bromoacetophenone hydrochloride 
• 58289-69-3 2-(4-bromophenyl)-2-hydroxyacetonitrile 
• 71559-14-3 2-azido-1-(4-bromophenyl)ethanone 

Downstream Products

• 10145-39-8 5-(4-bromo-phenyl)-4,5-dihydro-oxazol-2-ylamine 
• 137935-16-1 1-[2-(4-Bromo-phenyl)-2-hydroxy-ethyl]-3-cyclohexyl-thiourea 
• 479493-66-8 2-[2-(4-bromophenyl)-2-hydroxyethylamino]-4,6-dichloropyrimidine 
• 479493-65-7 6-[2-(4-bromophenyl)-2-hydroxyethylamino]-2,4-dichloropyrimidine 
• 137935-23-0 [5-(4-Bromo-phenyl)-4,5-dihydro-thiazol-2-yl]-cyclohexyl-amine 
• 1368418-27-2 6-(4-bromophenyl)morpholin-3-one 
• 1467061-26-2 6-chloro-5-[4-(5-oxomorpholin-2-yl)phenyl]-1H-indole-3-carbaldehyde 
• 1467058-77-0 6-chloro-5-[4-(5-oxomorpholin-2-yl)phenyl]-1H-indole-3-carboxylic acid 
• 1467061-25-1 N-(2-(4-bromophenyl)-2-hydroxyethyl)-2-chloroacetamide 
• 1131220-82-0 tert-butyl 2-(4-bromophenyl)morpholine-4-carboxylate 
• 83555-73-1 (RS)-2-(4-bromophenyl)morpholine 
• 913181-90-5 tert-butyl (2-(4-bromophenyl)-2-hydroxyethyl)carbamate 

Relevant academic research and scientific papers

Direct catalytic synthesis of unprotected 2-amino-1-phenylethanols from alkenes by using iron(II) phthalocyanine

Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products. Herein, we report that an exceptionally simple and inexpensive FeII complex efficiently catalyzes the direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity. This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.

Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists

A new series of morpholine derivatives has been identified as selective DA D3 receptor antagonists; their in vitro profile and pharmacokinetic data are provided.

Regio-selective synthesis of 1,2-aminoalcohols from epoxides and chlorohydrins

A simple and efficient procedure for the regio-selective synthesis of 1,2-aminoalcohols from terminal epoxides and chlorohydrins by using NaHMDS as the source of amine is reported. The wider scope and utility of this method is demonstrated.

Magnetically recoverable supported ruthenium catalyst for hydrogenation of alkynes and transfer hydrogenation of carbonyl compounds

A ruthenium (Ru) catalyst supported on magnetic nanoparticles (NiFe2O4) has been successfully synthesized and used for hydrogenation of alkynes at room temperature as well as transfer hydrogenation of a number of carbonyl compounds under microwave irradiation conditions. The catalyst shows excellent selectivity toward the desired products with very high yield even after five repeated uses.

OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS

The present invention is directed to compounds of Formula (I): Wherein R1, R2, Y, m and n are further defined in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

Asymmetric hydrogenation of α-primary and secondary amino ketones: Efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine

Two ss-receptor agonists (-)-denopamine and (-)-arbutamine were prepared in good yields and enantioselectivities by asymmetric hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of α-primary and secondary amino ketones were synthesized and hydrogenated to produce various 1,2-amino alcohols in good yields and with good enantioselectivies. This Rh electron-donating phosphine-catalyzed asymmetric hyderogenation repI resents one of the most promising and convenient approaches towards the asymmetric synthesis of chiral amino alcohols.

Cyclic voltammetry as an indicator of antioxidant activity

A series of compounds based around combining the neuroprotective properties of non-competitive N-methyl D-aspartic acid (NMDA) receptor antagonists with antioxidant functionalities have been prepared. The redox chemistry of these compounds has been evalua