913181-90-5Relevant academic research and scientific papers
Self-assembly of oxidation-responsive polyethylene glycol-paclitaxel prodrug for cancer chemotherapy
Dong, Chengyuan,Liu, Fusheng,Shen, Youqing,Xiang, Jiajia,Zhou, Quan,Zhou, Zhuxian
, p. 529 - 539 (2020/03/04)
Amphiphilic drug conjugates can self-assemble into nanovehicles for cancer drug delivery, but the key is to design stable yet intracellular labile drug linkers for drug retention during blood circulation but fast intracellular drug release. The conjugatio
Direct catalytic synthesis of unprotected 2-amino-1-phenylethanols from alkenes by using iron(II) phthalocyanine
Legnani, Luca,Morandi, Bill
supporting information, p. 2248 - 2251 (2016/02/18)
Aryl-substituted amino alcohols are privileged scaffolds in medicinal chemistry and natural products. Herein, we report that an exceptionally simple and inexpensive FeII complex efficiently catalyzes the direct transformation of simple alkenes into unprotected amino alcohols in good yield and perfect regioselectivity. This new catalytic method was applied in the expedient synthesis of bioactive molecules and could be extended to aminoetherification.
Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa
Lazarova, Tsvetelina I.,Jin, Lei,Rynkiewicz, Michael,Gorga, Joan C.,Bibbins, Frank,Meyers, Harold V.,Babine, Robert,Strickler, James
, p. 5022 - 5027 (2007/10/03)
A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit m
