41168-76-7

Upstream product

• 527-61-7 2,6-dimethyl-1,4-benzoquinone 
• 108-24-7 acetic anhydride 
• 4380-94-3 3,5-dimethyl-1,2,4-benzenetriol 
• 75-36-5 acetyl chloride 
• 7664-93-9 sulfuric acid 
• 4370-49-4 3,5-dimethyl-3,5-cyclohexadiene-1,2-dione 
• 7218-19-1 6,6-diacetoxy-2,4-dimethyl-cyclohexa-2,4-dienone 

Downstream Products

• 92421-43-7 2,4-dimethyl-3,5,6-trimethoxybenzaldehyde 
• 107301-77-9 2,4-dimethyl-3,5,6-trimethoxybenzyl alcohol 
• 107301-82-6 2,4-dimethyl-3,5,6-trimethoxybenzyl chloride 
• 107301-84-8 (2,3,5-trimethoxy-4,6-dimethylbenzyl)trimethylsilane 
• 1431987-18-6 8-(5-methoxy-2,4-dimethyl-3,6-dioxocyclohexa-1,4-dienyl)octyl nitrate 
• 1431987-13-1 6-(5-methoxy-2,4-dimethyl-3,6-dioxo cyclohexa-1,4-dienyl)hexyl nitrate 
• 1431987-16-4 10-(5-methoxy-2,4-dimethyl-3,6-dioxocyclohexa-1,4-dienyl)decyl nitrate 
• 3214-57-1 2-methoxy-3,5-dimethyl-2,5-cyclohexadiene-1,4-dione 
• 2913-40-8 3,5-dimethyl-2-hydroxy-p-benzoquinone 
• 92421-42-6 1,3-dimethyl-2,4,5-trimethoxybenzene 
• 4380-94-3 3,5-dimethyl-1,2,4-benzenetriol 

Relevant academic research and scientific papers

QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE

The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.

QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS

The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.

Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria

Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.

New Drug Delivery System for Crossing the Blood Brain Barrier

New ubiquinol analogs are disclosed, as well as methods of using these compounds to deliver drug moieties to the body.

Bi(OTf)3-catalyzed acylation of p-quinones: A facile synthesis of acylated hydroquinones

p-Quinones undergo smooth acylation with acetic anhydride in the presence of 2mol% of bismuth triflate under mild conditions to afford the corresponding 1,4-diacylated-2-acetoxylated hydroquinones in excellent yields with high selectivity.