412293-98-2

Basic information

• Product Name: 1-(phenylsulfonyl)piperazine hydrochloride
• Synonyms: 1-(phenylsulfonyl)piperazine hydrochloride
• CAS NO: 412293-98-2
• Molecular Weight: 262.76
• Mol File: 412293-98-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(phenylsulfonyl)piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(phenylsulfonyl)piperazine hydrochloride(412293-98-2)
• EPA Substance Registry System: 1-(phenylsulfonyl)piperazine hydrochloride(412293-98-2)

Safety Data

• Hazardous Substances Data: 412293-98-2(Hazardous Substances Data)

Usage

Common Use

Pharmaceutical intermediate in the synthesis of various drugs and medications

Salt Form

Derived from 1-(phenylsulfonyl)piperazine by adding hydrochloric acid

Pharmacological Properties

Investigated for its ability to modulate neurotransmitter systems in the brain

Potential Applications

Antidepressant or antipsychotic agent

Safety Precautions

Handle and use with caution due to possible adverse effects and toxicity if not handled properly

Importance

Significant chemical in the pharmaceutical industry for the development of new medications

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 77278-38-7 4-benzoylpiperazine-1-carboxylic acid tert-butyl ester 
• 253175-69-8 tert-butyl 4-(phenylsulfonyl)piperazine-1-carboxylate 

Downstream Products

• 1250276-76-6 C₂₆H₂₆N₄O₄S 
• 1250276-79-9 C₂₆H₂₆N₄O₃S 
• 1361216-10-5 1-(5-bromo-2-pyridinyl)-4-(phenylsulfonyl)piperazine 
• 16017-63-3 2-(4-(phenylsulfonyl)piperazin-1-yl)ethan-1-ol 
• 1361216-09-2 1,1,1,3,3,3-hexafluoro-2-(6-(4-(phenylsulfonyl)-1-piperazinyl)-3-pyridinyl)-2-propanol 
• 1323405-93-1 3-{4-[4-(4-benzenesulfonyl-piperazin-1-ylmethyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-piperidine-2,6-dione 

Relevant articles and documents

HSD17B13 INHIBITORS AND USES THEREOF

Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.

C-3 NOVEL TRITERPENE WITH C-17 AMINE DERIVATIVES AS HIV INHIBITORS

The present invention relates to to C-3 novel triterpene with C-17 amine derivatives of formula (I); or pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, prodrugs, compositions or combination thereof, wherein R1, R2, R3, R4, R5 and 'n' are as defined herein. The present invention also relates to pharmaceutical compositions comprising compounds of formula (I) and process for preparing them, and their use for the treatment of viral diseases and particularly HIV mediated diseases.

ANTIVIRAL PYRIMIDINES

Disclosed herein are novel compounds comprising substituted pyrimidines, pyrazolopyrimtdines, and imidazolopyrimidines, the syntheses thereof, and compositions thereof, including pharmaceutical compositions, comprising the novel pyrimidines, pyrazolopyrimtdines, imidazolpyrimidines and related compounds. Such compounds function to inhibit entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.