41262-33-3

Upstream product

• 99-90-1 para-bromoacetophenone 
• 25294-65-9 3-(4-bromophenyl)-2-propynoic acid 
• 21757-86-8 1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol 
• 1122-91-4 4-bromo-benzaldehyde 
• 108-86-1 bromobenzene 
• 76-02-8 trifluoroacetyl chloride 

Downstream Products

• 67-66-3 chloroform 
• 78080-34-9 N-butyl-4-bromo-benzamide 
• 4209-02-3 1-(4-bromophenyl)-2-chloroethan-1-one 
• 881650-48-2 (Z)-1,4-bis(4-bromophenyl)-2,3-dichlorobut-2-ene-1,4-dione 
• 1273584-13-6 (S)-5,5,5-trichloro-4-hydroxy-4-(4-bromophenyl)pentan-2-one 

Relevant academic research and scientific papers

Synthesis of Trihalomethyl Ketones from Trihalomethyl Carbinols (Hal = Cl, Br) Using 2-Iodoxybenzoic Acid

Abstract: An efficient method for the preparation of trihalomethyl (Cl, Br) ketones by the oxidation of trihalomethyl carbinols with 2-iodoxybenzoic acid in tert-butanol under heating has been developed. A series of trihalomethyl ketones have been synthesized through a simple, convenient, and environmentally friendly method with excellent yields.

Continuous flow reaction system for the synthesis of 2,2,2-trichloroacetophenone derivatives and its application

A continuous flow reaction system was developed for the synthesis of 2,2,2-trichloroacetophenone derivatives. When aryl propiolic acids and water were mixed with trichloroisocyanuric acid in DMF at 5 °C, the 2,2,2-trichloroacetophenone derivatives were formed within 5 min with good yields. In addition, the resulting mixture was flowed to react with amines to give the corresponding benzamide. This flow reaction system provided higher yields within shorter times than the batch reaction system.

Metal-Free Decarboxylative Trichlorination of Alkynyl Carboxylic Acids: Synthesis of Trichloromethyl Ketones

2,2,2-Trichloroacetophenone derivatives were synthesized via decarboxylative trichlorination from arylpropiolic acids and trichloroisocyanuric acid (TCCA). The reaction was performed in the presence of water at room temperature, and the desired products were obtained in good yields. The reaction showed good functional group tolerance towards halide, cyano, nitro, ketone, ester and aldehyde groups. In addition, the 2,2,2-trichloroacetophenone derivatives were readily transformed into esters, amides, and hydrazides. Based on experiments with H218O (water-18O), we proposed a cationic reaction pathway as the mechanism and suggested two different pathways for producing aryl- and alkyl-substituted propiolic acids. (Figure presented.).

A novel β-(oxy)alkyl radical during copper(I)-mediated stereoselective synthesis of (Z)-ene-1,4-diones in a reaction of 2,2,2-trichloro-1-phenylethanone

A novel β-(oxy)alkyl radical derived from trichloro methyl compound containing neither a suitably located C-C multiple bond nor a leaving group or a H-atom at the β-position of the radical in a reaction of 2,2,2-trichloro-1-phenyl-ethanone with 2 mol equiv each of CuCl and bpy in refluxing DCE under a N2 atm underwent intramolecular heterolysis (just like formation of intact radical cation-anion pair) during stereoselective radical dimerization to Z-ene-1,4-dione along with small amount of reductive dechlorination product. The stereochemistry was established by X-ray diffraction spectroscopy of various solid crystalline products.