4131-76-4

Usage

InChI:InChI=1/C5H10O2S/c1-4(3-8)5(6)7-2/h4,8H,3H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 21083-22-7 α-Methyl-β-propiothiolactone 
• 33325-40-5 3-(acetylthio)-2-methylpropanoic acid 
• 138682-17-4 2-(2-Methoxycarbonyl-propylsulfanyl)-piperidine-1-carboxylic acid methyl ester 
• 97101-46-7 methyl L-(+)-3-acetylthio-2-methylpropionate 
• 138682-18-5 (5R,8aS)-5-Mercapto-hexahydro-oxazolo[3,4-a]pyridin-3-one 
• 80-62-6 methacrylic acid methyl ester 
• 637-51-4 isothiocyanatobenzene 
• 124-41-4 sodium methylate 

Downstream Products

• 343329-56-6 C₈₈H₁₄₄O₄₈S₈ 

Relevant academic research and scientific papers

A thioesterase for chemoselective hydrolysis of S-acyl sulfanylalkanoates.

[figure: see text] A thioesterase, isolated from a strain of Alcaligenes sp. ISH108, chemoselectively hydrolyzes thiol esters. The application of the enzyme has been demonstrated in the preparation of the antihypertensive agent captopril.

Process Conditions for Production of D-β-Acetylthioisobutyric Acid from Methyl DL-β-Acetylthioisobutyrate with the Cells of Pseudomonas putida MR-2068

The process conditions concerned with the production of D-β-acetylthioisobutyric acid were investigated.Methyl DL-β-acetylthioisobutyrate as an enzyme substrate was produced from methyl methacrylate in 96.6percent yield by allowing 1.0 mol of methyl methacrylate to react with 1.6 mol of thioacetic acid at 80 deg C for 6 h.Through the study of hydrolytic reaction of methyl DL-β-acetylthioisobutyrate with the cells of Pseudomonas putida MR-2068, it was found that D-β-acetylthioisobutyric acid having more than 98percent (e. e.) optical purity was obtained when the reaction was done below pH 7.5 and below 50 deg C.For example, 10percent (w/v) methyl DL-β-acetylthioisobutyrate in the reaction mixture was asymmetrically hydrolyzed by 0.2percent (w/v) cells at 45 deg C at pH 7.0 for 18 h to give DAT having 98.2percent (e. e.) optical purity in 49.7percent yield.To prevent the decomposition and racemization of D-β-acetylthioisobutyric acid in the purification process, the use of a thin-film distillation apparatus for a continuous distillation was proposed to be an effective purification method.

A NEW SYNTHESIS OF OPTICALLY ACTIVE β-MERCAPTOCARBOXYLIC ACID ESTERS

Synthesis of optically active β-mercaptocarboxylic acid esters has been achieved by a new method utilizing optically active N-methoxycarbonylpiperidine derivative as a template which can be prepared from L-lysine by anodic oxidation.

Stereocontrol in the Intramolecular Nitrone Cycloaddition to Vinyl Sulphur Derivatives.

The intramolecular cycloaddition to vinyl sulphur derivatives of a series of nitrones featuring an alkyl or alkoxy substituted α-stereocenter on the tether connecting dipol and dipolarophile occurs in a competely stereoselective fashion to give 3',3-anti configurated products.The synthetic potentialities of this reaction is illustrated by the synthesis of a precursor of (d)-biotin.

Amide carbamates and amide oxime compounds

Amide oxime compounds are useful intermediates in the preparation of pesticidally active amide carbamate compounds.

A Novel Method for the Preparation of Thioformates and Thiols by using Thioformimidates

Several new S-alkylated thioformimidates were synthesized and their applications to the synthesis of thiolformates and thiols were investigated.Keywords - thioformimidates; thiols; thiolformates; thioformanilide; Michel-type addition