413614-15-0Relevant academic research and scientific papers
Cu and Au nanocomposites in catalytic olefination reaction
Nenajdenko, Valentine G.,Vasil'Kov, Alexander Yu.,Goldberg, Aleksey A.,Muzalevskiy, Vasiliy M.,Naumkin, Alexander V.,Podshibikhin, Vladislav L.,Shastin, Aleksey V.,Balenkova, Elizabeth S.
, p. 200 - 202 (2010)
Metal-vapor synthesis-prepared Cu, Ag, Au and bimetallic Au-Cu (optimal) nanocomposites catalyse olefination of hydrazones with polyhalomethanes.
Green, Catalyst-Free Reaction of Indoles with β-Fluoro-β-nitrostyrenes in Water
Aldoshin, Alexander S.,Tabolin, Andrey A.,Ioffe, Sema L.,Nenajdenko, Valentine G.
, p. 3816 - 3825 (2018/07/31)
The reaction of 2-fluoro-2-nitrostyrenes with various indoles was investigated. We found that the reaction proceeds as a Michael addition in a highly regioselective manner to form 3-(1-aryl-2-fluoro-2-nitroethyl)-1H-indoles. Thus, a green and catalyst-free synthesis of these compounds was developed using water as a reaction medium. The high effectiveness of this approach was demonstrated through the preparation of target products in up to 92 % isolated yield. Subsequent reduction of the nitro group was investigated. We found that due to the instability of the intermediate α-fluoro amines, the reduction led to non-fluorinated tryptamine derivatives.
New synthetic approach to α-fluoro-β-arylvinyl sulfones and their application in Diels-Alder reactions
Shastin, Aleksey V.,Nenajdenko, Valentine G.,Muzalevskiy, Vasiliy M.,Balenkova, Elizabeth S.,Fr?hlich, Roland,Haufe, Günter
, p. 9725 - 9732 (2008/12/22)
A new pathway towards α-fluoro-β-arylvinyl sulfones was elaborated. The reaction of β-bromo-β-fluorostyrenes with sodium 4-methylphenylsulfinate proceeds with maximum 94:6 stereoselectivity and 72-90% yields. The formed α-fluoro-β-arylvinyl sulfones were
Synthesis and Diels-Alder reactions of α-fluoro- and α-trifluoromethylacrylonitriles
Nenajdenko, Valentine G.,Muzalevskiy, Vasiliy M.,Shastin, Aleksey V.,Balenkova, Elizabeth S.,Haufe, Günter
, p. 818 - 826 (2008/03/14)
A novel synthetic method for the preparation of α-fluoro- and the still unknown α-trifluoromethylacrylonitriles is elaborated. The reaction of α-fluorovinylbromides and α-trifluoromethylvinylbromides with CuCN leads to the title compounds in good to high yields. While the α-fluoroacrylonitriles were isolated as mixture of Z/E-isomers, the α-trifluoromethylacrylonitriles were obtained as pure Z-isomers. The α-trifluoromethylacrylonitriles are shown to be excellent dienophiles for Diels-Alder reactions.
