52372-80-2

Basic information

• Product Name: Benzaldehyde, 4-chloro-, hydrazone
• Synonyms: [(4-chlorophenyl)methylidene]hydrazine;Benzaldehyde,4-chloro-,hydrazone
• CAS NO: 52372-80-2
• Molecular Formula: C7H7ClN2
• Molecular Weight: 154.599
• Mol File: 52372-80-2.mol
• Article Data: 58

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-chloro-, hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-chloro-, hydrazone(52372-80-2)
• EPA Substance Registry System: Benzaldehyde, 4-chloro-, hydrazone(52372-80-2)

Safety Data

• Hazardous Substances Data: 52372-80-2(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 7803-57-8 hydrazine hydrate 
• 5706-80-9 4-chlorobenzaldehyde thiosemicarbazone 
• 5315-86-6 4-chlorobenzaldehyde semicarbazone 
• 4980-30-7 N'-[(4-chlorophenyl)methylidene]-2-cyanoacetohydrazide 
• 74105-59-2 N'-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-hydrazinecarboxylic acid 9H-fluoren-9-ylmethyl ester 
• 154866-92-9 ethyl 4-(4-chlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate 
• 5948-71-0 4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one 

Downstream Products

• 56224-54-5 1,5-bis-(4-chloro-benzylidenehydrazino)-2,4-dinitro-benzene 
• 40092-34-0 C₁₁H₁₄ClN₃O 
• 40092-01-1 C₁₂H₁₆ClN₃O 
• 5263-17-2 4-chloro-1-(2,2-dichloroethenyl)benzene 
• 108574-15-8 1-chloro-4-[(1E)-2-chloro-3,3,3-trifluoro-1-propenyl]benzene 
• 108574-11-4 (Z)-1-chloro-4-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)benzene 
• 3510-48-3 4-chlorobenzaldehyde azine 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 
• 66482-30-2 (Z)-1-bromo-2-(4-chlorophenyl)ethylene 
• 66482-29-9 1-[(E)-2-bromoethenyl]-4-chlorobenzene 
• 18684-82-7 1-chloro-4-(2-chlorovinyl)benzene 
• 66482-29-9 1-(2-bromovinyl)-4-chlorobenzene 
• 19099-59-3 1-Chloro-4-((E)-2-chloro-2-fluoro-vinyl)-benzene 
• 71707-43-2 (E)-2-chloro-3-(4-chlorophenyl)acrylonitrile 

Relevant articles and documents

Hydrazone Based Dual – Responsive Colorimetric and Ratiometric Chemosensor for the Detection of Cu2+/F? Ions: DNA Tracking, Practical Performance in Environmental Samples and Tooth Paste

Colorimetric sensors have attracted wide scope of attentions due to its fascinating advantages, like handy, equipment-free and naked eye detections. In this investigation, a new and novel hydrazone based dual-responsive ratiometric/colorimetric chemosenso

Copper-Catalyzed Conjugate Addition of Carbonyls as Carbanion Equivalent via Hydrazones

Copper-catalyzed conjugate addition is a classic method for forming new carbon-carbon bonds. However, copper has never showed catalytic activity for umpolung carbanions in hydrazone chemistry. Herein, we report a facile conjugate addition of hydrazone catalyzed by readily available copper complexes at room temperature. The employment of mesitylcopper(I) and electron-rich phosphine bidentate ligand is a key factor affecting reactivity. The reaction allows various aromatic hydrazones to react with diverse conjugated compounds to produce 1,4-adducts in yields of about 20 to 99%.

Synergistic Relay Reactions To Achieve Redox-Neutral α-Alkylations of Olefinic Alcohols with Ruthenium(II) Catalysis

Herein, we report a ruthenium-catalyzed redox-neutral α-alkylation of unsaturated alcohols based on a synergistic relay process involving olefin isomerization (chain walking) and umpolung hydrazone addition, which takes advantage of the interaction between the two rather inefficient individual reaction steps to enable an efficient overall process. This transformation shows the compatibility of hydrazone-type “carbanions” and active protons in a one-pot reaction, and at the same time achieves the first Grignard-type nucleophilic addition using olefinic alcohols as latent carbonyl groups, providing a higher yield of the corresponding secondary alcohol than the classical hydrazone addition to aldehydes does. A broad scope of unsaturated alcohols and hydrazones, including some complex structures, can be successfully employed in this reaction, which shows the versatility of this approach and its suitability as an alternative, efficient means for the generation of secondary and tertiary alcohols.