41479-98-5Relevant articles and documents
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase
Fauber, Benjamin P.,Dragovich, Peter S.,Chen, Jinhua,Corson, Laura B.,Ding, Charles Z.,Eigenbrot, Charles,Labadie, Sharada,Malek, Shiva,Peterson, David,Purkey, Hans E.,Robarge, Kirk,Sideris, Steve,Ultsch, Mark,Wei, Binqing,Yen, Ivana,Yue, Qin,Zhou, Aihe
, p. 5683 - 5687 (2014)
A series of 3,6-disubstituted dihydropyrones were identified as inhibitors of human lactate dehydrogenase (LDH)-A. Structure activity relationships were explored and a series of 6,6-spiro analogs led to improvements in LDHA potency (IC50 50 = 30 nM).
INHIBITORS OF UNDECAPRENYL PYROPHOSPHATE SYNTHASE
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Page/Page column 170, (2008/06/13)
The present invention relates to compounds that are selective and/or potent inhibitors of UPPS. In addition to compounds which inhibit UPPS, the invention also provides pharmaceutical compositions comprising these compounds and methods of using these comp
5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
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, (2008/06/13)
The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the tre