41501-68-2

Upstream product

• 20618-08-0 β,β-dichloroacryloyl chloride 
• 108-88-3 toluene 
• 56-23-5 tetrachloromethane 
• 54731-27-0 1-p-methylphenyl-1-trimethylsiloxyethene 
• 75-62-7 Bromotrichloromethane 
• 80676-77-3 1-(1-t-butyldimethylsiloxyethenyl)-4-methylbenzene 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 118200-05-8 2-Pyrrolidin-1-yl-4-p-tolyl-[1,3]thiazine-6-thione 
• 118200-06-9 2-Morpholin-4-yl-4-p-tolyl-[1,3]thiazine-6-thione 
• 118200-25-2 6-Pyrrolidin-1-yl-4-p-tolyl-[1,3]thiazine-2-thione 
• 118200-18-3 Pyrrolidine-1-carbothioic acid ((Z)-3-pyrrolidin-1-yl-3-thioxo-1-p-tolyl-propenyl)-amide 
• 118200-19-4 Morpholine-4-carbothioic acid ((Z)-3-pyrrolidin-1-yl-3-thioxo-1-p-tolyl-propenyl)-amide 
• 106552-37-8 (E)-3,3-diphenyl-1-(p-tolyl)prop-2-en-1-one 
• 83239-26-3 (E)-3-Chloro-3-phenylsulfanyl-1-p-tolyl-propenone 
• 81376-00-3 1-(4-methylphenyl)-3,3-di(ethylthio)-2-propen-1-one 
• 41467-27-0 3,3-bis(methylthio)-1-(p-tolyl)prop-2-en-1-one 
• 81836-46-6 2-Chloro-2-pyrrolidinovinyl-(4-methylphenyl)-keton 
• 52039-38-0 2-dimethylamino-4-p-tolyl-[1,3]thiazine-6-thione 

Relevant academic research and scientific papers

Functionalized β,β-dichloroenones and β,β-dibromoenones as versatile building blocks: Synthesis and transformations

An efficient one-step synthesis of functionalized β,β-dichloroenones and β,β-dibromoenones was achieved via the Fe-catalyzed radical induced reaction between silyl enol ethers and carbon tetrachloride, bromotrichloromethane or carbon tetrabromide in moderate to good yields. This reaction proceeds through addition of the trichloromethyl or tribromomethyl radical group to the C[dbnd]C bond of the silyl enol ethers and subsequent base-induced elimination under mild conditions.

Reactions of trichloromethanesulfonyl chloride and carbon tetrachloride with silyl enol ethers catalyzed by a ruthenium(II) phosphine complex

The reactions of trichloromethanesulfonyl chloride with trimethylsilyl enol ethers of acetophenones in the presence of a ruthenium(II) phosphine complex gave 1-aryl-3,3-dichloropropen-1-one together with α-chloroacetophenones. The product ratio depended on the substituent on the aromatic ring of the silyl enol ether. The reactions of carbon tetrachloride with the silyl enol ethers under similar conditions afforded 1-aryl-3,3-dichloropropen-1-one in good yield.