41575-23-9

Usage

Compound class

Isoindolinone compounds 2-(2-chloroethyl)isoindolin-1-one belongs to a specific group of chemical compounds known as isoindolinones.

Physical appearance

White solid substance This describes the color and physical state of 2-(2-chloroethyl)isoindolin-1-one.

Solubility

Soluble in organic solvents 2-(2-chloroethyl)isoindolin-1-one can dissolve in certain organic solvents, which is important for its applications in chemical reactions and synthesis.

Odor

Characteristic odor 2-(2-chloroethyl)isoindolin-1-one has a distinct smell, which may be relevant for handling and storage purposes.

Use in pharmaceuticals and agrochemicals

Building block for biologically active compounds 2-(2-chloroethyl)isoindolin-1-one is used as a starting material in the synthesis of various pharmaceuticals and agrochemicals, as it can be converted into compounds with biological activity.

Use as a reagent

Organic chemical reactions 2-(2-chloroethyl)isoindolin-1-one can be used as a reagent in organic chemical reactions, facilitating the formation of desired products.

Research chemical

Medicinal chemistry As a research chemical, 2-(2-chloroethyl)isoindolin-1-one is valuable for studying and understanding the properties and behavior of isoindolinone compounds in the context of medicinal chemistry.

Potential applications

New materials development and organic synthesis Due to its unique chemical properties, 2-(2-chloroethyl)isoindolin-1-one may have future applications in the development of new materials and in the field of organic synthesis.

Upstream product

• 6270-06-0 N-(2-chlroethyl)phthalimide 
• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 87-41-2 2-benzofuran-1(3H)-one 
• 5334-06-5 2-(2-hydroxyethyl)-2,3-dihydro-1H-benzo[c]pyrrol-1-on 

Relevant academic research and scientific papers

Electroselective and Controlled Reduction of Cyclic Imides to Hydroxylactams and Lactams

An efficient and practical electrochemical method for selective reduction of cyclic imides has been developed using a simple undivided cell with carbon electrodes at room temperature. The reaction provides a useful strategy for the rapid synthesis of hydroxylactams and lactams in a controllable manner, which is tuned by electric current and reaction time, and exhibits broad substrate scope and high functional group tolerance even to reduction-sensitive moieties. Initial mechanistic studies suggest that the approach heavily relies on the utilization of amines (e.g., i-Pr2NH), which are able to generate α-aminoalkyl radicals. This protocol provides an efficient route for the cleavage of C-O bonds under mild conditions with high chemoselectivity.

Complementary synthetic approaches to constitutionally diverse N-aminoalkylated isoindolinones: Application to the synthesis of falipamil and 5-HT1A receptor ligand analogues

Different synthetic approaches for the elaboration of poly and diversely substituted isoindolinones tailed with constitutionally diverse aminoalkylated chains have been developed. The key step is based upon the preliminary assembly of the isoindolinone te

N-substituted azabicycloheptane derivatives, their preparation and use

Compounds of the formula I STR1 where the substituents have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.

Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives

A series of phthalimide and isoindolinone derivatives bridged to 4-(1,2- benzisothiazol-3-yl)-1-piperazinyl was prepared. The compounds were evaluated in vitro at dopamine D2 and serotonin 5-HT(1a) and 5-HT2 receptors and in vivo for their ability to antagonize the apomorphine-induced climbing response in mice. The effects of bridge length and conformation on the biological activity of these potential antipsychotic agents are discussed. A four-carbon spacer provided optimal activity within the two homologous series. Conformational investigations of the lead compound, isoindolinone 2, were conducted in an attempt to account for the superior activity observed for the butyl derivatives. On the basis of NMR and molecular modeling studies, two types of folded structures were proposed and several conformationally restrained analogues were synthesized. In general, restrictions incorporated within the linking bridge were detrimental to activity.