4160-72-9Relevant articles and documents
Models of DNA C1' radicals. Structural, spectral, and chemical properties of the thyminylmethyl radical and the 2'-deoxyuridin-1'-yl radical
Chatgilialoglu, Chryssostomos,Ferreri, Carla,Bazzanini, Rita,Guerra, Maurizio,Choi, Seung-Yong,Emanuel, Calvin J.,Horner, John H.,Newcomb, Martin
, p. 9525 - 9533 (2000)
The thyminylmethyl radical and the 2'-deoxyuridin-1'-yl radical were studied. The former radical was produced in laser flash photolysis (LFP) studies from two precursors derived from thyminylacetic acid, the N-hydroxypyridine-2-thione ester (PTOC ester),
Radiation-induced and photosensitized splitting of C5-C5′-linked dihydrothymine dimers: Product and laser flash photolysis studies on the oxidative splitting mechanism
Ito, Takeo,Shinohara, Hideki,Hatta, Hiroshi,Nishimoto, Sei-Ichi,Fujita, Shin-Ichi
, p. 8413 - 8420 (1999)
Radiation-induced and photosensitized one-electron oxidation of stereoisomeric C5-C5′-linked dihydrothymine dimers (1a,b[meso], meso compound of (5R,5′S)-bi-5,6-dihydrothymine; 1a,b[rac], racemic compound of (5R,5′R)-and (5S,5′S)-bi-5,6-dihydrothymines), which are the major products yielded by radiolytic reduction of 1-methylthymine (2a) and 1,3-dimethylthymine (2b) in aqueous solution, was studied to compare with the photoreactivating repair mechanism of cyclobutane pyrimidine photodimers. Reacting with sulfate radical anion (SO4.-), azide radical (N3.), or photoexcited anthraquinone-2-sulfonate (AQS) as oxidants, the C5-C5′-linked dihydrothymine dimers 1a,b split to regenerate the corresponding thymine monomers 2a,b along with 5,6-dihydrothymines (3a,b) in a pH dependent manner. The transient absorption spectra of 5,6-dihydrothymin-5-yl radicals (6a,b) were observed in the nanosecond laser flash photolysis of 1a,b in phosphate buffer under conditions of SO4.- generation. Both the product study and the laser flash photolysis study indicated an oxidative splitting mechanism by which one-electron oxidation of the C5-C5′-linked dimers 1a,b produces the radical cation intermediates (4a,b), which undergo facile fragmentation into 5,6-dihydrothymin-5-yl radicals 6a,b and C5-cations (5a,b), followed by deprotonation at C6 of 5a,b to regenerate the monomers 2a,b.
SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
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, (2019/01/04)
Provided is a compound having α4 integrin inhibitory action. The compound is a sulfonamide derivative represented by the following formula (I), or pharmaceutically acceptable salt thereof: where R1 to R5, e to h, D, and B represent those as described in the specification.
Universal Base
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Page/Page column 5, (2010/03/02)
The present invention provides artificial universal base capable of base pairing nonspecifically with any of four kinds of natural nucleic acid bases (A, T, G, and C) without the function to specifically recognize pairing natural nucleic acid bases for base pair formation. Universal base capable of base paring nonspecifically with four kinds of natural nucleic acid bases, wherein the universal base has a structure represented by the following chemical formula: wherein R represents a monovalent group other than a hydrogen atom.