41622-39-3Relevant academic research and scientific papers
Thiophospholipid compound and production method thereof
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Paragraph 0078-0083, (2019/10/29)
The invention discloses a thiophospholipid compound and a production method thereof. The production method of the sulfurphospholipid compound comprises the following production steps of (1) dissolving10-12 mmol of 1-n-olefin and 10 mmol of 1-mercapto-n-alkanoic acid in a solvent dichloromethane, adding 0.05-0.5 mmol of 2,2,-dimethoxy-2-phenylacetophenone to initiate a click reaction, and after the reaction is completed, conducting separation and purification by means of silica gel column chromatography to obtain thioalkanoic acid; and (2) dissolving the thioalkanoic acid product in dichloromethane, adding N,N'-carbonyldiimidazole for activation for 0.5-4 hours, adding a mixed dimethylsulfoxide solution of 1,8-diazabicyclo[5.4.0]undec-7-ene and glycerophosphoryl choline, and after a reaction is completed, conducting separation and purification to obtain a white solid product thioalkanoic acid glycerophosphoryl choline. The structure of the provided thiophospholipid compound contains thioether bonds which are easy to oxidize, so that the thiophospholipid compound is subjected to fast oxidation modification in an oxidant, and has better hydrophilicity.
Phosphocholine derivative inhibitors of phospholipase A2
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, (2008/06/13)
Phospocholine derivatives having the formula: STR1 in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A2. Methods of making and using the compounds are also disclosed.
S,S-Dialkyl Dithiocarbonates as a Convenient Source of Alkanethiols: an Improved Synthesis of Alkylthiocarboxylic Acids
Cadamuro, Silvano,Degani, Iacopo,Fochi, Rita,Regondi, Valeria
, p. 1070 - 1074 (2007/10/02)
A wide variety of β-alkylthiocarboxylic acids are obtained by addition of alkanethiols - generated in situ from S,S-dialkyl dithiocarbonates - to appropriate α,β-unsaturated carboxylic acids in good to excellent yields.
A NEW EFFICIENT AND VERSATILE SYNTHESIS OF ALKYL PHOSPHORYLCHOLINES
Magolda, R. L.,Johnson, P. R.
, p. 1167 - 1170 (2007/10/02)
A short and general synthetic method is described for the preparation of new phosphorylcholines.
