41637-05-2Relevant articles and documents
Evans, David J.,Green, Michael
, p. 183 - 184 (1987)
Versatile Route to trans-Platinum(II) Complexes via Manipulation of a Coordinated 3-(Pyridin-3-yl)propanoic Acid Ligand
Cabrera, Silvia,Navas, Francisco,Matesanz, Ana I.,Maroto, Marta,Riedel, Tina,Dyson, Paul J.,Quiroga, Adoracion G.
, p. 7200 - 7208 (2019/05/01)
We describe the direct coupling of alcohols and amines to a 3-(pyridin-3-yl)propanoic acid ligand coordinated to a Pt(II) to afford ester and amide derivatives. Using this approach, a family of trans-Pt(II) compounds with amine ligands bearing long perfluorinated chains was prepared, as these chains potentially endow the complexes with thermoactivatable properties. Related compounds with alkyl chains in place of the perfluorinated chains were also prepared as controls using the same direct coupling method. The stability of the complexes in solution, their reactivity with DNA and proteins, and their antiproliferative activity evaluated in tumorigenic (A2780 and A2780cisR) and nontumorigenic (HEK293) cells at 37 °C and following exposure to elevated temperatures (that mimic the temperatures employed in thermotherapy) were also studied to assess their utility as putative (thermoactivated) anticancer agents.
A long-lived ascorbate radical in the platinum(II) catalysed reductions of platinum(IV) antitumor drugs
Bose, Rathinda N.,Weaver, Evelyne L.
, p. 1797 - 1800 (2007/10/03)
A ling-lived ascorbate radical was characterized during the reduction of a series of platinum(IV) drugs; ascorbate reductions proceed through a platinum(IV)-ascorbate intermediate, the formation of which is catalysed by platinum(II).
