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15273-32-2

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15273-32-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 15273-32-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,2,7 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15273-32:
(7*1)+(6*5)+(5*2)+(4*7)+(3*3)+(2*3)+(1*2)=92
92 % 10 = 2
So 15273-32-2 is a valid CAS Registry Number.

15273-32-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Platinum,dichlorobis(methanamine)-, (SP-4-2)-

1.2 Other means of identification

Product number -
Other names trans-[Rh(ethylenediamine)2Cl2]NO3

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15273-32-2 SDS

15273-32-2Relevant articles and documents

In vitro activity, stability, and lipophilicity changes of cisplatin through substitution of different amine ligands

Divsalar, Adeleh,Eslami Moghadam, Mahboube,Mesbah, A. Wahid,Rahiminezhad, Arezo

, (2022/02/09)

In this study, several cisplatin analogs were designed to investigate the antitumor activity and lipophilicity effects in amine change. The amines of the cisplatin molecule were substituted with aliphatic amines in different analogs. The cytotoxicity of analogs against human colon cancer (HCT116) was investigated using MTT assay, and spectroscopic methods were used to determine the DNA binding mode. Cytotoxicity studies revealed cis-dichloro-dimethylamine-platinum has a lower IC50 (48.87?μM) than carboplatin (68.46?μM) and more than cisplatin (21?μM) against human colon cancer cells (HCT116), respectively. DNA denaturation study indicated that the stability of DNA in the presence of these compounds diminished and substitution of propylamine and methylamine groups increased DNA denaturation. Further, the interaction of the desired compounds with DNA proved to be a spontaneous process. Tm analysis also revealed that cisplatin, cis-dichloro-dimethylamine-platinum, and cis-dichloro-dipropylamine-platinum complexes made DNA double helix unstable via covalent bond, while cis-dichloro-dibutylamine-platinum and cis-dichloro-diisobutylamine-platinum stabilized DNA via electrostatic binding to DNA. The results of fluorescence studies showed that the quenching nature of cisplatin and methyl and propyl systems was dynamic, while the static quenching was observed in the presence of cis-dichloro-dibutylamine-platinum and cis-dichloro-diisobutylamine-platinum. The molecular docking simulations and DFT analysis were performed to investigate the binding sites and chemical behavior of cisplatin analogs, respectively. Molecular docking demonstrated that except cis-dichloro-diisobutylamine-platinum, other complexes had higher negative docking energy than cisplatin for interaction with DNA, and methyl and propyl complexes may be good candidates for anticancer drugs. Graphical abstract: Some anticancer Pt(II) complexes as cisplatin analogs were synthesized with aliphatic amines to investigate the lipophilicity effects. In vitro cytotoxicity effects were tested against human colon cancer (HCT116). Moreover, the modes of DNA binding with synthesized compounds were investigated using fluorescence spectra, DFT and molecular docking. [Figure not available: see fulltext.]

Molecular interaction fields vs. quantum-mechanical-based descriptors in the modelling of lipophilicity of platinum(iv) complexes

Ermondi, Giuseppe,Caron, Giulia,Ravera, Mauro,Gabano, Elisabetta,Bianco, Sabrina,Platts, James A.,Osella, Domenico

supporting information, p. 3482 - 3489 (2013/03/28)

We report QSAR calculations using VolSurf descriptors to model the lipophilicity of 53 Pt(iv) complexes with a diverse range of axial and equatorial ligands. Lipophilicity is measured using an efficient HPLC method. Previous models based on a subset of these data are shown to be inadequate, due to incompatibility of whole molecule descriptors between carboxylato and hydroxido ligands. Instead, the interaction surfaces of complexes with various probes are used as independent descriptors. Partial least squares modelling using three latent variables results in an accurate (R2 = 0.92) and robust model (Q2 = 0.87) of lipophilicity, that moreover highlights the importance of size and hydrophobicity terms and the modest relevance of hydrogen bonding.

SYNTHESIS OF (GLYCOLATO-O,O')DIAMMINEPLATINUM(II) AND ITS RELATED COMPLEXES

Totani, Tetsushi,Aono, Katsutoshi,Komura, Michihiro,Adachi, Yasuko

, p. 429 - 432 (2007/10/02)

Glycolatoplatinum(II) complexes, , having a novel five-membered ring structure were obtained by adding an equimolar quantity of glycolic acid to cis- (L: NH3, amines) in water followed by heating.These complexes have also been obtained by reaction of cis- with sodium glycolate in neutral aqueous solution.These complexes have been characterized by SIMS, IR, and NMR spectroscopy.

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