41661-56-7

Basic information

• Product Name: 1-Pyridin-2-ylmethylpiperidin-4-one
• Synonyms: CHEMBRDG-BB 4001982;1-PYRIDIN-2-YLMETHYLPIPERIDIN-4-ONE;1-Pyridin-2-ylmethylpiperidin-4-one95%;1-PYRIDIN-2-YLMETHYLPIPERIDIN-4-ONE 95%;Pyridin-2-ylmethylpiperidin-4-one;Zinc02559648;1-(2-PyridinylMethyl)-4-piperidinone
• CAS NO: 41661-56-7
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.24
• Product Categories: API intermediates
• Mol File: 41661-56-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 318.1 °C at 760 mmHg
• Flash Point: 146.2 °C
• Appearance: /
• Density: 1.149 g/cm³
• Vapor Pressure: 0.000368mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• PKA: 6.04±0.20(Predicted)
• CAS DataBase Reference: 1-Pyridin-2-ylmethylpiperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyridin-2-ylmethylpiperidin-4-one(41661-56-7)
• EPA Substance Registry System: 1-Pyridin-2-ylmethylpiperidin-4-one(41661-56-7)

Safety Data

• Hazardous Substances Data: 41661-56-7(Hazardous Substances Data)

Usage

General Description

1-Pyridin-2-ylmethylpiperidin-4-one, also known as P2MP4, is a chemical compound with a molecular formula C13H16N2O. It belongs to the class of heterocyclic organic compounds and contains a piperidin-4-one moiety with a pyridine ring attached to it. 1-Pyridin-2-ylmethylpiperidin-4-one is commonly used in pharmaceutical and research applications. It has been studied for its potential as a ligand in metal-catalyzed reactions and as a building block for the synthesis of various bioactive molecules and pharmaceutical drugs. Its unique structure makes it a versatile and valuable chemical in organic synthesis and drug discovery efforts.

InChI:InChI=1/C11H14N2O/c14-11-4-7-13(8-5-11)9-10-3-1-2-6-12-10/h1-3,6H,4-5,7-9H2

Upstream product

• 41661-47-6 piperidin-4-one 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 3731-51-9 2-(Aminomethyl)pyridine 
• 41979-39-9 4-piperidone hydrochloride 
• 215035-91-9 pyridin-2-ylmethyl methanesulphonate 
• 929876-97-1 2-(iodomethyl)pyridine 
• 55401-97-3 2-(Bromomethyl)pyridine 
• 158867-78-8 N,N-bis(2-ethoxycarbonylethyl)-N-(2-pyridilmethyl)amine 

Downstream Products

• 1293289-28-7 3-(1-(phenylsulfonyl)-1H-indol-3-yl)-4-(1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)-1H-indol-3-yl)furan-2,5-dione 
• 1217131-50-4 4-(3-{[1-(pyridin-2-ylmethyl)piperidin-4-yl]amino}phenoxy)quinolin-2(1H)-one 
• 616898-64-7 oxo-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-oxo-acetic acid methyl ester 
• 170364-57-5 enzastaurin 
• 594827-31-3 1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indole 
• 616898-68-1 1-(1-(pyridin-2-ylmethyl)piperidin-4-yl)indoline 

Relevant articles and documents

Very Strong and Selective Complexation of Small Metal Ions by a Highly Preorganised Open-chain Bispidine-based Ligand

Synthesis of 3,7-bis(2-pyridylmethyl)-3,7-diazabicyclononane DPB, with very rigid nitrogen-bridge reinforcement gives an adamantane-like structure once a metal ion is coordinated to DPB, and shows how remarkable stability enhancement and selectivity for metal ions on the basis of size can be achieved in non-macrocyclic ligands.

Development of a manufacturing process for 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole: A key intermediate for protein kinase C inhibitor LY317615

This contribution describes process development leading to the production of 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole (11). The title compound 11 was produced via a Leimgruber-Batcho indole synthesis using key intermediates 2-(2,2-dimethoxyethyl

Strategies for the synthesis of N-(azacycloalkyl)bisindolylmaleimides: Selective inhibitors of PKCβ

N-(Azacycloalkyl)bisindolylmaleimides 1 have been identified to be selective inhibitors of PKCβ. This manuscript will describe the synthetic approaches employed to prepare this class of compounds that resulted in development of efficient methods for prepa