41661-57-8

Basic information

• Product Name: 1-((Pyridin-3-yl)methyl)piperidin-4-one
• Synonyms: 1-(PYRIDIN-3-YLMETHYL)PIPERIDIN-4-ONE;1-((PYRIDINE-3-YL)METHYL)PIPERIDINE-4-ONE;1-(pyridin-3-ylmethyl)piperidin-4-one(SALTDATA: FREE);1-[(3-Pyridyl)methyl)]-4-piperidone
• CAS NO: 41661-57-8
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.24
• Mol File: 41661-57-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 335.9°C at 760 mmHg
• Flash Point: 156.9°C
• Appearance: /
• Density: 1.149g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-((Pyridin-3-yl)methyl)piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((Pyridin-3-yl)methyl)piperidin-4-one(41661-57-8)
• EPA Substance Registry System: 1-((Pyridin-3-yl)methyl)piperidin-4-one(41661-57-8)

Safety Data

• Hazardous Substances Data: 41661-57-8(Hazardous Substances Data)

Usage

General Description

1-((Pyridin-3-yl)methyl)piperidin-4-one is a chemical compound with the molecular formula C12H16N2O. It belongs to the class of organic compounds known as dialkylarylamines, which are a kind of tertiary alkylarylamines that contain at least two aryl groups and at least one secondary or tertiary alkyl group. 1-((Pyridin-3-yl)methyl)piperidin-4-one is also known as 4-(pyridin-3-ylmethyl)piperidin-4-one or N-[(3-pyridinyl)methyl]-4-piperidinone. It is a heterocyclic compound containing a piperidine ring fused to a pyridine ring and a ketone group. This chemical is utilized in various pharmaceutical and research applications due to its potential biological activities and pharmacological properties.

InChI:InChI=1/C11H14N2O/c14-11-3-6-13(7-4-11)9-10-2-1-5-12-8-10/h1-2,5,8H,3-4,6-7,9H2

Upstream product

• 3731-52-0 3-Aminomethylpyridine 
• 26822-37-7 N,N-dimethyl-4-oxopiperidinium iodide 
• 1445-73-4 1-Methyl-4-piperidone 
• 1225498-23-6 methyl 4-oxo-1-(pyridin-3-ylmethyl)piperidine-3-carboxylate 
• 33611-47-1 3-[N,N-di(2-methoxycarbonylethyl)aminomethyl] pyridine 
• 190012-32-9 1-nicotinoyl-4-piperidone ethylene acetal 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 41979-39-9 4-piperidone hydrochloride 
• 6959-48-4 3-chloromethylpyridinium chloride 
• 502924-69-8 1-[(3-pyridyl)methyl]-4-piperidone ethylene acetal 

Downstream Products

• 1241699-38-6 C₂₅H₂₀F₂N₂O 

Relevant articles and documents

Synthesis and Antimicrobial Evaluation of Novel Chiral 2-Amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Derivatives

New N-substituted-2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine derivatives were synthesized employing a convenient one-pot three-component method and their structures were characterized by 1H-NMR and single crystal X-ray diffraction analysis. All the synthesized compounds were in vitro screened for antimicrobial activity against Gram-positive (Sarcina lutea) and Gram-negative bacteria (Escherichia coli). In this work, we introduced a chiral residue on the tetrahydropyridine nitrogen, the hitherto the less investigated position on this pharmacophore in order to explore the effect. The antibacterial results showed that the synthesized compounds were active only against Gram-positive bacteria and the (R)-enantiomers displayed a greater antimicrobial potency than their (S)-counterparts. The structure–activity relationship here investigated may provide some interesting clues for future development of tetrahydrothienopyridine derivatives with higher antimicrobial activity.

Novel symmetrical trans-bis-Schiff bases of N-substituted-4- piperidones: Synthesis, characterization, and preliminary antileukemia activity mensurations

A series of novel symmetrical trans-bis-Schiff bases (11a, 11b, 11c, 11d, 11e, 11f, 11g, 11h, 11i, 11j, 11k, 11l, 11m) were designed and prepared as novel anticancer analogues, with the trans-configuration confirmed by X-ray diffraction. Preliminary inhibitory effects of these compounds on CML K562 cell growth were investigated, and the potential analogue 11e showed an excellent anti-leukemia activity (IC50=6.35 μg/mL), which is higher than that of the clinical drug 5-fluorouracil (IC50=8.48 μg/mL). Complete assignments had been achieved for the title compounds by spectroscopic techniques, and their structure-activity relationships have been studied.

Green chemistry approach to the synthesis of N-substituted piperidones

An efficient green chemistry approach to the synthesis of N-substituted piperidones and piperidines was developed and applied to the synthesis of 1-(2-pyridinylmethyl)-piperidin-4-one, 1, a key starting material for the synthesis of LY317615, an antiangio