41697-19-2

Upstream product

• 98-88-4 benzoyl chloride 
• 936-02-7 2-Hydroxybenzoylhydrazine 
• 532-32-1 sodium benzoate 
• 198974-12-8 2-[2-(4-chlorophenyl)-2-oxoethylidene]-5-phenylfuran-3(2H)-one 
• 142273-50-5 Z-2-methoxycarbonylmethylene-5-phenyl-2,3-dihydro-3-furanone 
• 69-72-7 salicylic acid 
• 65-85-0 benzoic acid 
• 119-36-8 methyl salicylate 

Downstream Products

• 18233-24-4 2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenol 
• 1523272-57-2 2-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl benzoate 

Relevant academic research and scientific papers

[30]metallacrown-10 compounds: [mn(c14h9n2o3) (ch3oh) ] 10·5ch2cl2· 16 ch3oh·h2o and [fe(c14h9n2o3) (ch3ch) ] 10·3ch2cl2· 12.5 Ch3oh·5h2o

A plauar decanuclear 30-membered core ring is present in the new manganese (see picture) and iron [30]azametallacrown-10 compounds. These compounds were prepared by using the pentadentate ligand N-phenylsalicylhydrazidate, and the metal atoms in each ring adopt a propeller configuration and have alternating Λ/Δ stereochemistries.

Synthesis and antioxidant activity of 1,3,4-oxadiazoles and their diacylhydrazine precursors derived from phenolic acids

Eight 1,3,4-oxadiazole derivatives containing phenolic acid moieties (7a-h) and eight of their diacylhydrazine precursors (6a-h) were synthesized, characterized using spectroscopic methods and examined by scavenging of stable DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals. The most potent phenolic 1,3,4-oxadiazoles showed better DPPH scavenging activity in comparison with their corresponding diacylhydrazine precursors as a result of participation of both aromatic rings and a 1,3,4-oxadiazole moiety in resonance stabilization of the formed phenoxyl radical. Four diacylhydrazines (6d, 6e, 6g, and 6h) and four 1,3,4-oxadiazoles (7d, 7e, 7g and 7h) with the best DPPH scavenging activity, were chosen for further evaluation of their antioxidant potential through various assays. The investigated compounds exerted pronounced ABTS radical scavenging capacity, moderate to good H2O2 scavenging properties and strong ferric ion reducing capacity. Further in vitro evaluation of the antioxidant properties of the most active compounds demonstrated their protective effects in normal lung fibroblasts MRC-5 against hydrogen peroxide induced oxidative stress. Diacylhydrazine 6h increased two times the activity of glutathione peroxidase in treated cells in comparison with a control sample and did not affect the superoxide dismutase activity.

Chemistry of 2-ylidenefuran-3(2H)-ones: XIX. Reaction of 5-aryl-2(oxoylidene)furan-3(2H)-ones with carboxylic acid hydrazides

2-[2-(4-Chlorophenyl)-2-oxoethylidene]-5-phenylfuran-3(2H)-one and methyl (5-aryl-3-oxo-2,3-dihydrofuran-2-ylidene)acetates react with carboxylic acid hydrazides to give the corresponding 3-substituted 2-acyl-6-aryl-3-hydroxy-2,3- dihydropyridazin-4(1H)-ones. Specificities of the product structure are discussed.

Excited state intramolecular proton transfer reaction and luminescent properties of the ortho-hydroxy derivatives of 2,5-diphenyl-1,3,4-oxadiazole

Luminescent properties of several ortho-hydroxy derivatives of 2,5-diphenyl-1,3,4-oxadiazole were studied in solvents of different polarity and protolytic ability and compared with the analogous derivatives of 1,3-oxazole, studied by us earlier. Evaluatio

Pentafluorophenyl ester activation for the preparation of N,N'-diaroylhydrazines

Procedures are reported for the preparation of N,N'-diaroylhydrazines using pentafluorophenyl (Pfp) ester activation of aryl carboxylic acids. Mild conditions which avoid intermediate protection of ring substituents, allows the synthesis of both symmetrical and unsymmetrical diaroylhydrazines in high yields. The recent discovery of potent HIV-1 integrase inhibition by N,N'-bis-salicylhydrazine (1) highlights the potential importance of this class of compounds. The stability of pre-activated Pfp ester intermediates and the facility with which N,N'-diaroylhydrazines can be synthesized using this procedure (stirring at room temperature in DMF) may make the method particularly attractive for synthesis of hydrazide libraries.

A simple synthesis of 4,5-dihydro-5H-1,3,4-benzoxadiazepin-5-ones

A simple method for the synthesis of 4,5-dihydro-5H-1,3,4-benzoxadiazepin-5-ones 4 based on the reaction of salicyclic hydrazide (1) with one carbon insertion units, such as carboxylic acid anhydrides, acid chlorides, and ortho esters is reported.

The Hydroxy Derivatives of 2,5-Diphenyl-1,3,4-oxadiazole

An unambiguous synthesis for each of the monohydroxy derivatives of 2,5-diphenyl-1,3,4-oxadiazole is reported.