41718-53-0

Upstream product

• 109-65-9 1-bromo-butane 
• 6683-92-7 1-phenylpentan-2-one 
• 927-77-5 n-propylmagnesium bromide 
• 73083-29-1 α-butylbenzeneacetaldehyde 
• 106-31-0 butanoic acid anhydride 
• 855910-37-1 2-(4-chloro-phenyl)-3-oxo-hexanenitrile 
• 105909-68-0 3-oxo-2-phenyl-hexanenitrile 
• 876478-75-0 1-phenyl-2-propyl-hexane-1,2-diol 

Relevant academic research and scientific papers

Photochemical Asymmetric Nickel-Catalyzed Acyl Cross-Coupling

Photochemical enantioselective nickel-catalyzed cross-coupling reactions are difficult to implement. We report a visible-light-mediated strategy that successfully couples symmetrical anhydrides and 4-alkyl dihydropyridines (DHPs) to afford enantioenriched α-substituted ketones under mild conditions. The chemistry does not require exogenous photocatalysts. It is triggered by the direct excitation of DHPs, which act as a radical source and as a reductant, facilitating the turnover of the chiral catalytic nickel complex.