41731-23-1

Basic information

• Product Name: 2-Bromo-5-methylthiazole
• Synonyms: Thiazole,2-broMo-5-Methyl-;2-Bromo-5-methylthizaole;2-BROMO-5-METHYL-THIAZOLE;2-BROMO-5-METHYL-1,3-THIAZOLE;2-Bromo-5-methyl-thiazole Hydrobromide
• CAS NO: 41731-23-1
• Molecular Formula: C₄H₄BrNS
• Molecular Weight: 178.05
• Product Categories: Halides;Thiazoles, Isothiazoles &Benzothiazoles;ADVANCED CHEMICALS;Heterocycles;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 41731-23-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 192-200°C
• Flash Point: 71.778 °C
• Appearance: /
• Density: 1.702 g/cm³
• Vapor Pressure: 0.598mmHg at 25°C
• Refractive Index: 1.5730 to 1.5770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, Methanol (Slightly)
• PKA: 1.32±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Bromo-5-methylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-methylthiazole(41731-23-1)
• EPA Substance Registry System: 2-Bromo-5-methylthiazole(41731-23-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41-36
• Safety Statements: 26-39
• Hazardous Substances Data: 41731-23-1(Hazardous Substances Data)

Usage

Uses

2-Bromo-5-methylthiazole is a brominated thiazole compound for proteomics research.

InChI:InChI=1/C4H4BrNS/c1-3-2-6-4(5)7-3/h2H,1H3

Upstream product

• 7305-71-7 5-methyl-2-thiazol-2-amine 
• 7789-45-9 copper(II)bromide 
• 3581-89-3 5-methylthiazole 

Downstream Products

• 847547-16-4 2-iodo-5-methylthiazole 
• 118113-05-6 1-(5-methyl-thiazol-2-yl)-piperazine 
• 1187451-04-2 tert-butyl [tert-butoxycarbonyl(6-{[4-(5-methylthiazol-2-yl)benzyl](pyridin-2-ylsulfonyl)aminomethyl}pyridin-2-yl)amino]acetate 
• 1206708-88-4 2,4-Dibromo-5-methyl-1,3-thiazole 

Relevant articles and documents

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

Photoswitchable triple hydrogen-bonding motif

Photochromic bis(thiazol-4-yl)maleimides, displaying enhanced binding affinity to complementary melamine receptors in their ring-closed switching state, have been developed and could pave the way to light-responsive supramolecular assemblies.

THIAZOLE DERIVATIVE

A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient, wherein: X1 and X2 are different from each other and represent a sulfur atom or a carbon atom; R1 represents a phenyl group; a substituted phenyl group; a phenyl group condensed with a hetero aromatic ring; a pyridyl group; or a pyridyl group condensed with a hetero aromatic ring; R2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms substituted with 1 to 5 halogen atoms, an alkoxy group having 1 to 6 carbon atoms, an alkanoyl group having 1 to 5 carbon atoms, or a hydroxyalkyl group having 1 to 6 carbon atoms, A represents a group which is represented by the formula. The present invention provides an inhibitory substance against ALK5 which is a TGF-β type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.