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(17beta)-3-(tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-17-ol is a synthetic steroidal compound derived from estradiol, a primary estrogen hormone in humans. (17beta)-3-(tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-17-ol features a tetrahydro-2H-pyran-2-yl group at the 3-position and a hydroxyl group at the 17th position of the estradiol molecule. It is not found naturally and is predominantly utilized in research and medical studies to explore the structure-activity relationships of steroid hormones and their possible therapeutic uses.

41781-86-6

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41781-86-6 Usage

Uses

Used in Pharmaceutical Research:
(17beta)-3-(tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-17-ol serves as a research chemical, aiding in the investigation of the structure-activity relationships of steroid hormones. This understanding is crucial for the development of new pharmaceuticals targeting hormonal imbalances and related conditions.
Used in Medical Studies:
In the medical field, (17beta)-3-(tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-17-ol is applied to study the potential therapeutic applications of steroid hormones. It can provide insights into the treatment of various disorders that are influenced by estrogen levels, such as menopausal symptoms, osteoporosis, and certain cancers.
Used in Drug Development:
(17beta)-3-(tetrahydro-2H-pyran-2-yloxy)estra-1,3,5(10)-trien-17-ol is also utilized in the development of new drugs that aim to modulate estrogen activity. This can lead to the creation of medications with fewer side effects and greater efficacy in treating specific health issues.

Check Digit Verification of cas no

The CAS Registry Mumber 41781-86-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,7,8 and 1 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 41781-86:
(7*4)+(6*1)+(5*7)+(4*8)+(3*1)+(2*8)+(1*6)=126
126 % 10 = 6
So 41781-86-6 is a valid CAS Registry Number.

41781-86-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (8R,9S,13S,14S,17S)-13-methyl-3-(oxan-2-yloxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

1.2 Other means of identification

Product number -
Other names Estradiol-3-tetrahydropyranylether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:41781-86-6 SDS

41781-86-6Downstream Products

41781-86-6Relevant academic research and scientific papers

The use of basic resin in the preparation of tetrahydropyranyl derivatives of alcohols and phenols

Chaturvedi, Devdutt,Kumar, Atul,Ray

, p. 437 - 438 (2007/10/03)

A quick and efficient method for the preparation of tetrahydropyranyl (THP) derivatives of phenols and alcohols using a basic resin IRA-400 (iodide) is described.

SYNTHESIS OF 2-PROPYNYL ETHERS OF STEROID ALCOHOLS

Pouzar, Vladimir,Schneiderova, Lenka,Drasar, Pavel,Strouf, Oldrich,Havel, Miroslav

, p. 1888 - 1902 (2007/10/02)

2-Propynyl ethers, derived from steroid alcohols with hydroxyl in position 3β, 17 or 20, were prepared by reaction with propargyl bromide and sodium hydroxide under conditions of phase transfer catalysis.Other hydroxy groups in the steroid molecule were protected with the methoxymethyl or 2-tetrahydropyranyl group.

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