418772-22-2

Upstream product

• 113075-66-4 1-(6-bromo-3,4-dihydro-2-naphthyl)pyrrolidine 
• 100-39-0 benzyl bromide 
• 4133-35-1 6-bromo-2-tetralone 
• 123-75-1 pyrrolidine 
• 4133-35-1 C₁₀H₁₀BrO₄S^(1-)*Na⁽¹⁺⁾ 

Downstream Products

• 1246650-79-2 C₁₇H₁₅BrO 
• 418772-23-3 (1R,9S,10R)-1-benzyl-5-bromo-10-hydroxy-10-methyl-tricyclo[7.3.1.0(2,7)]trideca-2,4,6-trien-13-one1(R)-benzyl-5-bromo-10(R)-hydroxy-10-methyl-tricyclo[7.3.1.0_2,7]trideca-2,4,6-trien-13-one 
• 418772-24-4 4a(S)-benzyl-7-bromo-2-ethoxy-3,4,4a,9-tetrahydro-phenanthrene 

Relevant academic research and scientific papers

PHENANTHRENONE COMPOUNDS, COMPOSITIONS AND METHODS

The present invention is directed to compounds of Formula (I) or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.

Tricyclic Compound, Compositions, and Methods

The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.

Glucocorticoid receptor modulators

The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.

Glucocorticoid receptor modulators

The present invention provides non-steroidal compounds of Formula I, including prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.

Process for the preparation of non-steroidal glucocorticoid receptor modulators

A process for preparing a compound of the formula useful as a non-steroidal glucocorticoid receptor modulator.

Glucocorticoid receptor modulators

The present invention provides non-steroidal compounds of Formula I, and prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.

Process for the preparation of non-steroidal glucocorticoid receptor modulators

A process for preparing a compound of the formula useful as a non-steroidal glucocorticoid receptor modulator.

Glucocorticoid receptor modulators

The present invention provides non-steroidal compounds of Formula I, and prodrugs and pharmaceutically acceptable salts thereof, which are selective modulators (e.g., agonists, partial agonists and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides pharmaceutical compositions containing these compounds and methods for using these compounds to treat animals requiring glucocorticoid receptor agonist or antagonist therapy. Glucocorticoid receptor modulators are useful to treat diseases, such as obesity, diabetes, inflammation and others as described below. The present invention also provides processes for preparing these compounds.