418785-06-5Relevant academic research and scientific papers
Synthesis of substrate analogues as potential inhibitors for Mycobacterium tuberculosis enzyme MshC
Patel, Krishnakant,Song, Fengling,Andreana, Peter R.
, p. 10 - 18 (2017/11/07)
Mycothiol cysteine ligase (MshC) is a key enzyme in the mycothiol (MSH) biosynthesis and a promising target for developing new anti-mycobacterial compounds. Herein, we report on the synthesis of substrate analogues, as potential inhibitors, for the MshC e
Synthesis of 1-D- and 1-L-myo-inosityl 2-N-acetamido-2-deoxy-α-D-glucopyranoside establishes substrate specificity of the Mycobacterium tuberculosis enzyme AcGI deacetylase
Nicholas, Gillian M.,Eckman, Lisa L.,Kovac, Pavol,Otero-Quintero, Sarah,Bewley, Carole A.
, p. 2641 - 2647 (2007/10/03)
Mycothiol (MSH, 1-D-myo-inosityl 2-(N-acetyl-L-cysteinyl)amido-2-deoxy-α-D-glucopyranoside) is the principal low molecular weight thiol in actinomycetes. The enzyme 1-D-myo-inosityl 2-N-acetamido-2-deoxy-α-D-glucopyranoside deacetylase (AcGI deacetylase)
Total synthesis and proof of structure of mycothiol bimane
Nicholas, Gillian M.,Kovac, Pavol,Bewley, Carole A.
, p. 3492 - 3493 (2007/10/03)
Mycothiol is a low-molecular weight thiol produced by actinomycetes that serves to protect these organisms from oxidative stress and alkylating agents. We report the total synthesis of mycothiol bimane (1) which is a commonly isolated derivative of mycoth
