58357-84-9

Basic information

• Product Name: 2-(3-CHLOROPHENYL)ACETAMIDE
• Synonyms: 2-(3-CHLOROPHENYL)ACETAMIDE;3-chloroBenzeneacetamide
• CAS NO: 58357-84-9
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.61
• Mol File: 58357-84-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 129.5-130.5 °C
• Boiling Point: 344.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.256±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.05±0.40(Predicted)
• CAS DataBase Reference: 2-(3-CHLOROPHENYL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLOROPHENYL)ACETAMIDE(58357-84-9)
• EPA Substance Registry System: 2-(3-CHLOROPHENYL)ACETAMIDE(58357-84-9)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 58357-84-9(Hazardous Substances Data)

Usage

General Description

2-(3-Chlorophenyl)acetamide is an organic chemical compound characterized by its incorporation of chlorine, phenyl group and acetamide group. This chemical falls into the category of acetanilides, which are derivatives of aniline with acetyl group substituted to the amine group. The presence of a chlorophenyl group suggests it has at least some degree of hydrophobicity, and it likely interacts with other chemical compounds via pi-stacking and hydrogen bonding. It may be used in chemical synthesis, possibly as an intermediate step in the creation of more complex chemicals. However, as with many chemicals, caution should be exercised in handling it due to potential hazards associated with its use.

Upstream product

• 1529-41-5 3-chloro-benzeneacetonitrile 
• 41904-39-6 3-chloro-benzeneacetyl chloride 
• 1878-65-5 3-chlorophenylacetic acid 

Downstream Products

• 621-79-4 cinnamamide 
• 14062-29-4 ethyl 2-(3-chlorophenyl)acetate 
• 77418-76-9 3-(3-Chloro-phenyl)-4-phenyl-piperidine-2,6-dione 
• 18166-64-8 4-chlorocinnamide 
• 77418-81-6 3-(3-Chloro-phenyl)-4-(4-chloro-phenyl)-piperidine-2,6-dione 
• 18254-00-7 4-methyl-cinnamic acid amide 
• 77418-86-1 3-(3-Chloro-phenyl)-4-p-tolyl-piperidine-2,6-dione 
• 511302-28-6 methyl N-(3-chlorobenzyl)carbamate 
• 1202782-48-6 N'-(4-{[3-(3-chlorobenzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide 
• 1202783-63-8 3-(3-chlorobenzyl)-5-[(4-methylphenyl)sulphonyl]-1,2,4-thiadiazole 
• 1202783-62-7 4-{[3-(3-chlorobenzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylaniline 
• 1202783-64-9 5-(3-chlorobenzyl)-1,3,4-oxathiazol-2-one 
• 58357-88-3 3-(3-chloro-phenyl)-4-phenyl-3H-pyridine-2,6-dione 

Relevant articles and documents

Hypervalent iodine catalyzed hofmann rearrangement of carboxamides using oxone as terminal oxidant

Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions. Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields.

Synthesis and Biological Evaluation of a Series of Substituted 4,5-Diphenylpyridine-2,6(1H,5H)-diones

We report the synthesis of a series of disubstituted 4,5-diphenylpyridine-2,6(1H,5H)-diones (8), (10), (12)-(21), their characterization by 1H and 13 C n.m.r. spectroscopy and their receptor binding affinities for catecholamine and benzodiazepine receptors.

Design of Inhibitors from the Three-Dimensional Structure of Alcohol Dehydrogenase. Chemical Synthesis and Enzymatic Properties

Inhibitors of liver alcohol dehydrogenase were designed from the three-dimensional structure of the enzyme.The ligand to the catalytic zinc ion is an amide group or, better, a formamide group.With the latter function, a hydrogen bond between the NH group and the hydroxyl group of Ser-48 may be formed.The hydrophobic substrate binding site brings structural restraints. α-ω bifunctional molecules show good inhibitory properties possibly due to the interactions with polar residues at the entrance of the substrate binding site.