58357-84-9

Usage

Uses

Used in Chemical Synthesis:
2-(3-Chlorophenyl)acetamide is used as a chemical intermediate for the synthesis of more complex compounds. Its unique structure, which includes a chlorine atom and a phenyl group, allows it to participate in various chemical reactions, making it a versatile building block in the creation of advanced chemical products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(3-Chlorophenyl)acetamide is used as a starting material for the development of new drugs. Its chemical properties, such as hydrophobicity and the ability to form hydrogen bonds, make it a promising candidate for the design of novel therapeutic agents.
Used in Material Science:
2-(3-Chlorophenyl)acetamide is used as a component in the development of new materials with specific properties. Its hydrophobic nature and potential to interact with other compounds through pi-stacking can contribute to the creation of materials with tailored characteristics for various applications, such as in electronics or coatings.
Safety Considerations:
As with many chemicals, caution should be exercised when handling 2-(3-Chlorophenyl)acetamide due to potential hazards associated with its use. Proper safety measures, including the use of personal protective equipment and adherence to safety protocols, are essential to minimize risks during its synthesis, storage, and application.

Upstream product

• 1529-41-5 3-chloro-benzeneacetonitrile 
• 41904-39-6 3-chloro-benzeneacetyl chloride 
• 1878-65-5 3-chlorophenylacetic acid 

Downstream Products

• 621-79-4 cinnamamide 
• 14062-29-4 ethyl 2-(3-chlorophenyl)acetate 
• 77418-76-9 3-(3-Chloro-phenyl)-4-phenyl-piperidine-2,6-dione 
• 18166-64-8 4-chlorocinnamide 
• 77418-81-6 3-(3-Chloro-phenyl)-4-(4-chloro-phenyl)-piperidine-2,6-dione 
• 58357-88-3 3-(3-chloro-phenyl)-4-phenyl-3H-pyridine-2,6-dione 
• 1202783-64-9 5-(3-chlorobenzyl)-1,3,4-oxathiazol-2-one 
• 1202783-62-7 4-{[3-(3-chlorobenzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylaniline 
• 1202783-63-8 3-(3-chlorobenzyl)-5-[(4-methylphenyl)sulphonyl]-1,2,4-thiadiazole 
• 511302-28-6 methyl N-(3-chlorobenzyl)carbamate 
• 1202782-48-6 N'-(4-{[3-(3-chlorobenzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide 
• 18254-00-7 4-methyl-cinnamic acid amide 
• 77418-86-1 3-(3-Chloro-phenyl)-4-p-tolyl-piperidine-2,6-dione 

Relevant academic research and scientific papers

Hypervalent iodine catalyzed hofmann rearrangement of carboxamides using oxone as terminal oxidant

Hofmann rearrangement of carboxamides to carbamates using Oxone as an oxidant can be efficiently catalyzed by iodobenzene. This reaction involves hypervalent iodine species generated in situ from catalytic amount of PhI and Oxone in the presence of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) in aqueous methanol solutions. Under these conditions, Hofmann rearrangement of various carboxamides affords corresponding carbamates in high yields.

Nitrile biotransformation by whole cells of Aspergillus sp. PTCC 5266

Aspergillus sp. PTCC 5266 exhibited nitrile-hydrating activity over a broad pH range from 6.0 to 10.0 at 26°C. It hydrated 4-nitrophenylacetonitrile, 2-chlorobenzonitrile and 3-chlorobenzonitrile to their corresponding carboxylic acids and amides, while benzyl cyanide, benzonitrile, 4-tolunitrile, cyclohexanecarbonitrile, 4-chlorobutyronitrile and isobutyronitrile gave carboxylic acids as the sole products. The maximum whole-cell nitrile-hydrating activity was observed at pH 7.0.

Synthesis and Biological Evaluation of a Series of Substituted 4,5-Diphenylpyridine-2,6(1H,5H)-diones

We report the synthesis of a series of disubstituted 4,5-diphenylpyridine-2,6(1H,5H)-diones (8), (10), (12)-(21), their characterization by 1H and 13 C n.m.r. spectroscopy and their receptor binding affinities for catecholamine and benzodiazepine receptors.

Design of Inhibitors from the Three-Dimensional Structure of Alcohol Dehydrogenase. Chemical Synthesis and Enzymatic Properties

Inhibitors of liver alcohol dehydrogenase were designed from the three-dimensional structure of the enzyme.The ligand to the catalytic zinc ion is an amide group or, better, a formamide group.With the latter function, a hydrogen bond between the NH group and the hydroxyl group of Ser-48 may be formed.The hydrophobic substrate binding site brings structural restraints. α-ω bifunctional molecules show good inhibitory properties possibly due to the interactions with polar residues at the entrance of the substrate binding site.