41915-99-5

Usage

Chemical structure

Urea derivative with a pyridine group attached to one of the nitrogen atoms

Application in medicinal chemistry

Potential antineoplastic agent

Targeted cancer types

Non-small cell lung cancer and other solid tumors

Antimicrobial properties

Investigated for combating drug-resistant bacterial infections

Research areas

Shown promise in various areas, including medicinal and industrial settings

Upstream product

• 3731-52-0 3-Aminomethylpyridine 
• 79-44-7 N,N-Dimethylcarbamoyl chloride 
• 54528-33-5 phenyl (pyridin-3-ylmethyl)carbamate 
• 124-40-3 dimethyl amine 

Downstream Products

• 1570232-78-8 N′-{[4-(hydroxydiphenylmethyl)pyridin-3-yl]methyl}-N,N-dimethylurea 
• 1570232-70-0 N′-[(4-tert-butylpyridin-3-yl)methyl]-N,N-dimethylurea 
• 1570232-67-5 N′-[2-hydroxy-2,2-diphenyl-1-(pyridin-3-yl)ethyl]-N,N-dimethylurea 

Relevant academic research and scientific papers

DIAZABICYCLOOCTANE DERIVATIVES COMPRISING A QUATERNERY AMMONIUM GROUP FOR USE AS ANTIBACTERIAL AGENTS

Compounds of Formula (I), pharmaceutical compositions comprising these compounds and their use in treating bacterial infection is disclosed.

Control of site of lithiation of 3-(Aminomethyl)pyridine derivatives

Lithiation of N-(pyridin-3-ylmethyl)pivalamide, tert-butyl N-(pyridin-3-ylmethyl)carbamate, and N,N-dimethyl-N′-(pyridin-3-ylmethyl) urea with tert-butyllithium (3 equiv) in anhydrous tetrahydrofuran at -78 °C takes place on the nitrogen and on the ring at the 4-position. The dilithium reagents thus obtained react with various electrophiles to give the corresponding substituted derivatives in high yields. On the other hand, regioselective side-chain lithiation occurs with lithium diisopropylamide (3.3 equiv) at -20 to 0 °C. A mixture of ring and side-chain substitution products is obtained with n-butyllithium as the lithium reagent. Treatment of one of the ring-substituted products with trifluoroacetic anhydride in dichloromethane under reflux conditions led to formation of the corresponding 1H-pyrrolo[3,4-c]pyridine in high yield. Georg Thieme Verlag Stuttgart . New York.