4195-17-9

Basic information

• Product Name: 4-NITROPHENYL TRIMETHYLACETATE
• Synonyms: 4-NITROPHENYL PIVALATE;4-NITROPHENYL TRIMETHYLACETATE;p-nitrophenyl pivalate;4-Nitrophenyl trimethylacetate, 98+%;Propanoic acid, 2,2-dimethyl-, 4-nitrophenyl ester;4-Nitrophenylacetic acid trimethyl ester;2,2-Dimethylpropionic acid p-nitrophenyl;2,2-Dimethylpropionic acid p-nitrophenyl ester
• CAS NO: 4195-17-9
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.23
• EINECS: 224-076-1
• Product Categories: Acetics acid and esters;Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks
• Mol File: 4195-17-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 92-95 °C(lit.)
• Boiling Point: 364.51°C (rough estimate)
• Flash Point: 136.5 °C
• Appearance: light yellow crystalline powder
• Density: 1.2446 (rough estimate)
• Vapor Pressure: 0.000258mmHg at 25°C
• Refractive Index: 1.4960 (estimate)
• CAS DataBase Reference: 4-NITROPHENYL TRIMETHYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-NITROPHENYL TRIMETHYLACETATE(4195-17-9)
• EPA Substance Registry System: 4-NITROPHENYL TRIMETHYLACETATE(4195-17-9)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 24/25-36/37
• WGK Germany: 3
• Hazardous Substances Data: 4195-17-9(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

Uses

4-Nitrophenyl trimethylacetate was used as sensitive probe to study the catalytic activity of carboxypeptidase Y.

General Description

4-Nitrophenyl trimethylacetate undergoes hydrolysis catalysed by cytoplasmic aldehyde dehydrogenase in presence of NAD+, NADH, propionaldehyde, chloral hydrate, diethylstilboestrol and p-nitrobenzaldehyde (modifiers).

InChI:InChI=1/C11H13NO4/c1-11(2,3)10(13)16-9-6-4-8(5-7-9)12(14)15/h4-7H,1-3H3

Upstream product

• 100-02-7 4-nitro-phenol 
• 3282-30-2 pivaloyl chloride 
• 1014-66-0 trimethyl(4-nitrophenoxy)silane 
• 37170-49-3 trimethylsilyl 2,2-dimethylpropionate 
• 69515-74-8 mitomycin-C 
• 159857-66-6 Carbonic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-phenyl-propionylamino}-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-benzyl ester 4-nitro-phenyl ester 
• 75-98-9 Trimethylacetic acid 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 108-95-2 phenol 
• 4920-92-7 pivalic acid phenyl ester 
• 18997-19-8 Chloromethyl pivalate 
• 32707-03-2 thallium(I) 4-nitrophenoxide 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 27069-03-0 N-butyl-2,2-dimethylpropanamide 
• 14909-78-5 tert-butyl hydroperoxide 
• 14609-74-6 p-nitrophenolate 
• 34949-25-2 pivalate de methyle d3 
• 14065-07-7 2-Hydroxy-5-nitro-diphenylsulfid 
• 354116-70-4 2-[5-(2,2-dimethyl-propionyloxy)-2-methoxycarbonylamino-phenyl]-2-phenylsulfanyl-propionic acid 
• 354116-69-1 5-(2,2-dimethyl-propionyloxy)-3-methyl-2-oxo-3-phenylsulfanyl-2,3-dihydro-indole-1-carboxylic acid methyl ester 
• 354116-65-7 C-methoxy-N-(4'-trimethylacetyloxyphenyl)-O-(2-phenylsulfanylpropanoyl)hydroxamic acid 
• 354116-64-6 C-methoxy-N-(4-trimethylacetyloxyphenyl)hydroxamic acid 
• 26209-45-0 N-benzyl-2,2-dimethylpropanamide 
• 120226-49-5 N-(4-methoxybenzyl)pivalamide 
• 120226-55-3 N-pivaloyl-p-chlorophenylmethylamine 
• 686-96-4 N-tert-butyltrimethylacetamide 

Relevant articles and documents

Efficient mitomycin C coupling with stable p-nitrophenyl-benzyl carbonates using N-hydroxybenzotriazole as a catalytic additive

Mitomycin C benzyl carbamates were prepared in high yield from stable p-nitrophenyl carbonates in the presence of catalytic amounts of 1-hydroxybenzotriazole/diisopropylethylamine in DMF.

Enantioselective, Lewis Base-Catalyzed, Intermolecular Sulfenoamination of Alkenes

A method for the catalytic, enantioselective, intermolecular, 1,2-sulfenoamination of alkenes is described. Functionalization is achieved through the intermediacy of an enantioenriched, configurationally stable thiiranium ion generated by Lewis base activation of a readily available sulfur electrophile. A diverse set of anilines and benzylamines react with different styrenes to afford products in good yield and stereoselectivity. Downstream manipulation of the products is facilitated by deprotonation of the amines to enable carbon-sulfur bond cleavage.

Erbium(III) chloride: A very active acylation catalyst

Erbium(iii) chloride is a powerful catalyst for the acylation of alcohols and phenols. The reaction works well for a large variety of simple and functionalized substrates by using different kinds of acidic anhydrides (Ac 2O, (EtCO)2O, (PriCO)2O, (Bu tCO)2O, and (CF3CO)2), without isomerization of chiral centres. Moreover, the catalyst can be easily recycled and reused without significant loss of activity. CSIRO 2007.