41992-33-0Relevant academic research and scientific papers
Copper(I)-induced addition of amines to unactivated nitriles: The first general one-step synthesis of alkyl amidines
Rousselet,Capdevielle,Maumy
, p. 6395 - 6398 (1993)
Cu(I)Cl promotes the condensation of acetonitrile 1a and benzonitrile 1b with primary and secondary amines 2a-g into amidines 3a-j under mild conditions, in high to quantitative yields. Stoichiometric formation of Cu(I)-amidines complexes allows to control the degree of substitution of resulting amidines.
