69981-57-3

Upstream product

• 14777-29-8 methyl acetimidate 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 
• 146656-29-3 4-benzyl-3-methyl-1,2,4-oxadiazol-5(4H)-one 
• 62-55-5 thioacetamide 
• 75-05-8 acetonitrile 
• 124-42-5 acetamidine hydrochloride 

Downstream Products

• 41992-33-0 N,N'-dibenzylacetamidine 
• 14321-27-8 N-ethylbenzylamine 
• 307520-61-2 C₁₄H₁₄N₂O₃ 
• 307520-56-5 C₁₈H₂₄N₂O₃ 

Relevant academic research and scientific papers

Readily prepared resin-bound thioimidates as reagents for the synthesis of amidines

The use of commercially available resins to prepare novel and stable polymer supported thioimidates was investigated. Polymer supported thioimidates were found to enable acetamidine formation in a convenient manner, with a significantly easier work-up than solution-phase reactions.

Sulfated tungstate catalyzed activation of nitriles: addition of amines to nitriles for synthesis of amidines

An efficient and mild method for the synthesis of amidines by direct nucleophilic addition of amines to nitriles using sulfated tungstate as heterogeneous catalyst is described. Highlight of the method is its applicability for the synthesis of amidines using a wide variety of amines including ammonia as ammonium acetate and nitriles. Catalyst is mildly acidic, stable, easy to prepare and separate from the reaction mass.

Carboxylic acid derivatives that inhibit the binding of integrins to their receptors

A method for the inhibition of the binding of α4β1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and to the use of such compounds either a above, or in formulations for the control or prevention of diseases states in which α4β1 is involved.

3-Methyl-4H-[1,2,4]-oxadiazol-5-one: A versatile synthon for protecting monosubstituted acetamidines

The utilization of 3-methyl-4H-[1,2,4]-oxadiazol-5-one as a versatile protected acetamidine is demonstrated through employment in a variety of synthetic sequences. The potassium salt (2a) or the neutral form (2b) is alternatively shown to be superior for

Copper(I)-induced addition of amines to unactivated nitriles: The first general one-step synthesis of alkyl amidines

Cu(I)Cl promotes the condensation of acetonitrile 1a and benzonitrile 1b with primary and secondary amines 2a-g into amidines 3a-j under mild conditions, in high to quantitative yields. Stoichiometric formation of Cu(I)-amidines complexes allows to control the degree of substitution of resulting amidines.