420107-69-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 420107-68-2 (2R,5R)-2-[(1S,2S)-2-Benzyloxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyloxy-propyl]-5-[(S)-2-benzyloxycarbonyl-2-(4-benzyloxy-3,5-dichloro-benzoylamino)-ethyl]-1-hydroxy-pyrrolidine-2-carboxylic acid benzyl ester 
• 420107-74-0 (2R,5R)-2-[(1S,2S)-2-Benzyloxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyloxy-propyl]-5-[(S)-2-benzyloxycarbonyl-2-(4-benzyloxy-3,5-dichloro-benzoylamino)-ethyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 420107-63-7 (R)-2-[(1S,2S)-2-Benzyloxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyloxy-propyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 420107-62-6 1-[1-benzyloxycarbonylamino-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-3-tert-butyl-dihydro-pyrrolo[1,2-c]oxazole-7a-carboxylic acid benzyl ester 
• 420107-64-8 2-[2-benzyloxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-trimethylsilanyloxy-propyl]-1-oxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid benzyl ester 
• 420107-72-8 (R)-2-[(1S,2S)-2-Benzyloxycarbonylamino-3-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-propyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 420107-73-9 (S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-methanesulfonyloxy-propionic acid benzyl ester 
• 420107-71-7 (S)-4-[(S)-((3R,7aR)-3-tert-Butyl-1-oxo-dihydro-pyrrolo[1,2-c]oxazol-7a-yl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 420107-61-5 (S)-4-[(R)-((3R,7aR)-3-tert-Butyl-1-oxo-dihydro-pyrrolo[1,2-c]oxazol-7a-yl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester 
• 420107-67-1 (R)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-iodo-propionic acid benzyl ester 
• 420107-66-0 (S)-2-(4-Benzyloxy-3,5-dichloro-benzoylamino)-3-hydroxy-propionic acid benzyl ester 
• 81286-82-0 (3R,7aS)-3-tert-Butyl-tetrahydro-pyrrolo[1,2-c]oxazol-1-one 
• 60022-62-0 L-serine benzyl ester hydrochloride 

Downstream Products

• 198710-92-8 (-)-Kaitocephalin 
• 420107-70-6 (2R,5R)-2-((1S,2R)-2-Benzyloxycarbonylamino-2-carboxy-1-hydroxy-ethyl)-5-[(S)-2-benzyloxycarbonyl-2-(4-benzyloxy-3,5-dichloro-benzoylamino)-ethyl]-pyrrolidine-1,2-dicarboxylic acid dibenzyl ester 

Relevant academic research and scientific papers

The first synthesis of kaitocephalin based on the structure revision

A total synthesis of kaitocephalin (2), a glutamate receptor antagonist, was accomplished employing a novel stereoselective C-C bond forming reaction of a nitrone (8) and a halide (11) with zinc in aqueous solvent under sonication as a key step. The absolute configuration of kaitocephalin was confirmed to be 2R,3S,4R,7R,9S.