42017-94-7

Usage

Uses

Used in Agricultural Industry:
[4-(4-chlorobenzoyl)phenoxy]acetic acid is used as a herbicide for controlling broadleaf weeds in various agricultural settings. It functions by mimicking the natural plant hormone auxin, which interferes with the growth of the weeds and ultimately leads to their control.
Used in Pharmaceutical Industry:
[4-(4-chlorobenzoyl)phenoxy]acetic acid is studied for its potential use in the treatment of certain types of cancer. It has demonstrated the ability to inhibit the proliferation of cancer cells, making it a compound of interest for researchers in the pharmaceutical industry.

Upstream product

• 42019-78-3 4-chloro-4'-hydroxybenzophenone 
• 122-01-0 4-chloro-benzoyl chloride 
• 100-66-3 methoxybenzene 
• 10547-60-1 4-chloro-4'-methoxybenzophenone 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 1416575-97-7 2-[4-(4-chlorobenzoyl)phenoxy]-N-(pyridin-3-yl)acetamide 

Relevant academic research and scientific papers

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N′-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were synthesized in good to excellent yields. Some of the triketones displayed potent in vitro Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one, II-13, displayed high, broad-spectrum, and postemergent herbicidal activity at the dosage of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, II-13 showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that II-13 might have potential as a herbicide for weed control in maize and canola fields. II-13 is the first HPPD inhibitor showing good crop safety toward canola.

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

We synthesized and evaluated a series of compounds for their allosteric modulation at the Kv11.1 (hERG) channel. Most compounds were negative allosteric modulators of [3H]dofetilide binding to the channel, in particular 7f, 7h-j and 7p. Compounds 7f and 7p were the most potent negative allosteric modulators amongst all ligands, significantly increasing the dissociation rate of dofetilide in the radioligand kinetic binding assay, while remarkably reducing the affinities of dofetilide and astemizole in a competitive displacement assay. Additionally, both 7f and 7p displayed peculiar displacement characteristics with Hill coefficients significantly distinct from unity as shown by e.g., dofetilide, further indicative of their allosteric effects on dofetilide binding. Our findings in this investigation yielded several promising negative allosteric modulators for future functional and clinical research with respect to their antiarrhythmic propensities, either alone or in combination with known Kv11.1 blockers.