42054-12-6

Basic information

• Product Name: Propanoic acid, 2,2-dimethyl-, 2-phenylhydrazide
• CAS NO: 42054-12-6
• Molecular Formula: C11H16N2O
• Molecular Weight: 192.261
• Mol File: 42054-12-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2,2-dimethyl-, 2-phenylhydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2,2-dimethyl-, 2-phenylhydrazide(42054-12-6)
• EPA Substance Registry System: Propanoic acid, 2,2-dimethyl-, 2-phenylhydrazide(42054-12-6)

Safety Data

• Hazardous Substances Data: 42054-12-6(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 100-63-0 phenylhydrazine 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 28669-35-4 3-(tert-butyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one 
• 78848-20-1 3-tert-butyl-1,4-dihydro-1-phenyl-1,2,4-benzotriazinyl radical 
• 41372-75-2 N-phenylhydrazone pivalyl chloride 
• 79201-98-2 5-tert-Butyl-2-(4-methoxy-phenyl)-3-phenyl-3H-[1,3,4,2]thiadiazaphosphole 2-sulfide 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

PREPARATION OF HYDRAZIDES USING SILICON TETRACHLORIDE AS COUPLING AGENT

Silicon tetrachloride proved to be an effective reagent for the preparation of hydrazides from carboxylic acids.Yields were comparable to those obtained via N,N'-dicyclohexylcarbodiimide (DCC) and the procedure was used to synthesize some hydrazides which are difficult to obtain otherwise.