42122-75-8

Usage

Chemical Properties

Pale yellow crystal

Uses

Methyl 5-amino-2-chlorobenzoate

InChI:InChI=1/C8H8ClNO2/c1-12-8(11)6-4-5(10)2-3-7(6)9/h2-4H,10H2,1H3

Upstream product

• 67-56-1 methanol 
• 89-54-3 2-chloro-5-aminobenzoic acid 
• 6307-82-0 2-chloro-5-nitro-benzoic acid methyl ester 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 1185221-13-9 C₈H₆ClN₃O₂ 
• 7439-89-6 iron 
• 144-55-8 sodium hydrogencarbonate 

Downstream Products

• 89951-56-4 4-chloro-5-hydroxymethyl aniline 
• 475596-72-6 methyl 2-chloro-5-[3-(2-methoxy-4-(5-phenylpentyloxy)phenyl)propanoylamino]benzoate 
• 886435-64-9 2-chloro-5-[(2-methyl-6-trifluoromethyl-pyridine-3-carbonyl)-amino]-benzoic acid methyl ester 
• 209222-45-7 1-[1-(2-toluoylmethyl)-2-oxo-5-pivaloyl-8-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl]-3-(3-methoxycarbonyl-4-chlorophenyl)urea 
• 111362-50-6 5-amino-2-chloro-benzamide 
• 937236-97-0 2-chloro-5-(5-nitro-pyridine-2-ylamino)-benzoic acid methyl ester 
• 942631-59-6 methyl 2-chloro-5-{[3-fluoro-5-(trifluoromethyl)benzoyl]amino}benzoate 
• 924859-46-1 C₈H₆Cl₂O₄S 
• 61508-36-9 4-chloro-3-methoxy-carbonylbenzenesulfonamide 
• 1172621-32-7 2-chloro-5-(6-chloro-pyrazin-2-ylamino)-benzoic acid methyl ester 
• 355368-67-1 2-chloro-5-(5-formyl-furan-2-yl)-benzoic acid methyl ester 
• 1232505-83-7 methyl 5-amino-4-bromo-2-chlorobenzoate 
• 1294496-55-1 N-(4-chloro-3-methoxycarbonyl-phenyl)-2-methyl-5-[(1-methylcyclohexylcarbonylamino)methyl]-benzamide 
• 1343457-99-7 6-chloro-3,3-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-5-carboxylic acid 

Relevant academic research and scientific papers

The structural influence in the stability of polymer-bound diazonium salts

Various new diazonium ions on a polymeric support that have a variety of counterions and complexation with crown ethers have been prepared, and the thermal stability of these resins over a larger temperature interval has been investigated. Nonisothermal k

Pd-Co catalysts prepared from palladium-doped cobalt titanate precursors for chemoselective hydrogenation of halonitroarenes

Bimetallic Pd-Co catalysts supported on the mixed oxides CoTiO3-CoO-TiO2 (CTO) were synthesized via the thermal reduction of Pd-doped cobalt titanates PdxCo1-xTiO3 and evaluated for the chemoselective hydrogenation of halonitroarenes to haloarene-amines. The nominal Pd mass percentage of the Pd-Co/CTO systems was varied from 0.0 to 0.50. After the thermal reduction of PdxCo1-xTiO3 at 500 °C for 3 h, Pd was completely reduced and Co was partially reduced, producing a mixture of ionic Co, metallic Co, and TiO2-rutile species to give the supported bimetallic catalysts. The metallic cobalt content increased with the Pd content of the precursor. The catalytic activity toward 4-chloronitrobenzene increased with the Pd content; however, >0.1 mass% Pd decreased the chemoselectivity toward 4-chloroaniline due to the formation of the hydrodehalogenation product—aniline. The 0.1Pd-Co/CTO system was used as a model catalyst to produce haloarene-amine building blocks for linezolid, loxapine, lapatinib, and sorafenib with >98% conversion, 96% chemoselectivity, and no hydrohalogenation products. Finally, recycling tests of the 0.1Pd-Co/CTO catalyst showed loss of activity and selectivity during the third cycle due to catalyst deactivation. Regeneration treatments, every two catalytic cycles, allowed six operation cycles without loss of chemoselectivity and only a slight decrease in catalytic activity during the last cycle.

Synthesis and herbicidal activities of novel thiazole PPO inhibitors

Background: Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is a key enzyme in the biosynthesis of chlorophyll and heme, also the target of different types of herbicides. Thiazole compounds shown excellent biological activity, can be designed by using active groups docking for new PPO inhibitors. Objective: The objective of this study was to synthsize a series of aryl thiazole compounds as PPO inhibitors. Methods: In this study, a series of aryl thiazole compounds derivatives 11a-l were obtained from 2-chloro-5-nitrobenzoic acid as the starting material via esterification, Iron powder reduction, diazoti-zation, Hantzsch reaction and final acylation. All synthesized compounds have been tested for their herbicidal activities as a PPO inhibitors. Results: The Petri dish test indicated that all compounds exhibited good herbicidal activities at 200 mg/L using culture dish. And the post-emergence tests showed that at 150g.ai/ha on weed stem leaf spray treatment, some of the title compounds exhibited 80% inhibition rate against the dicotyle-donou weeds Amaranthus retroflexus and Eclipta prostrate. Conclusion: Good activity was noted for some compounds that compounds 11a, 11b, 11c, 11g, 11h had 80% inhibition on stems and leaves of Amaranthus retroflexus at 150g.ai/ha.

COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

Aryl bithiazole compound and application

The invention discloses an aryl bithiazole compound and application. A series of aryl bithiazole compounds are prepared in the invention, and application of the compounds is researched. According to biological activity test results, the aryl bithiazole compound provided by the invention has excellent herbicidal activity, has wide herbicide controlling spectrum to wheat, sorghum, barnyard grass, cucumber, oilseed rapes and radish, has a high inhibition rate on broadleaf weeds, and particularly has obvious inhibitory effects on amaranthus retroflexus and eclipta prostrate.

PREPARATION AND METHODS OF USE FOR ORTHO-ARYL 5- MEMBERED HETEROARYL-CARBOXAMIDE CONTAINING MULTI-TARGETED KINASE INHIBITORS

The present disclosure relates to compounds of the Formula (I): and pharmaceutically acceptable salts, as kinase modulators, compatible with the Type-II inhibition of kinases.

NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.

NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES

A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.

One-pot microwave-assisted selective azido reduction/tandem cyclization in condensed and solid phase with nickel boride

An efficient and inexpensive method using microwave-assisted irradiation with Ni2B for the syntheses of aromatic amines, pyrrolobenzodiazepines as well as pyrroloquinazolinones was developed. This protocol was applied in the tandem resin-cleavage, azido reduction, and cyclization of compounds 3 and 5 that afforded substituted pyrrolo[2,1-c][1,4] benzodiazepines 4 and 6 in a one-pot manner. The microwave-assisted irradiation reactions enhanced yields with very short reaction times in contrast to the conventional thermal reactions. Georg Thieme Verlag Stuttgart.

Chemoselective aromatic azido reduction with concomitant aliphatic azide employing Al/Gd Triflates/Nal and ESI-MS mechanistic studies

Aluminium and gadolinium inflates catalyze the chemoselective reduction of aromatic azides to the corresponding amines in combination with sodium iodide. This mild chemoselective method has been applied to the synthesis of various aryl amines, C2azido-substituted pyrrolo[2,1-c]-[1,4]benzodiazepines, and fused[2,1b]quinazolinones by an intramolecular azido reduction tandem cyclization reaction. Interestingly, this methodology selectively reduces aryl azides with enhanced yields and proceeds in shorter reaction times than previous strategies. The mechanistic aspects have been investigated and the intermediates associated with this selective transformation have been intercepted and characterized by online monitoring of the reaction by ESI-MS.