4214-80-6

Basic information

• Product Name: 5-chloro-N-methylpyridin-2-amine
• Synonyms: 2-PyridinaMine, 5-chloro-N-Methyl-;5-chloro-N-methylpyridin-2-amine;UKRORGSYN-BB BBR-009506;5-Chloro-2-(MethylaMino)pyridine;5-Chloro-2-MethylaMinopyridine;5-Chloro-N-Methyl-2-pyridineaMine;5-Chloro-N-methyl-2-pyridinamine
• CAS NO: 4214-80-6
• Molecular Formula: C₆H₇ClN₂
• Molecular Weight: 142.59
• Mol File: 4214-80-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 247℃
• Flash Point: 103℃
• Appearance: /
• Density: 1.250
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 5-chloro-N-methylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-N-methylpyridin-2-amine(4214-80-6)
• EPA Substance Registry System: 5-chloro-N-methylpyridin-2-amine(4214-80-6)

Safety Data

• Hazardous Substances Data: 4214-80-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

5-Chloro-2-methylaminopyridine is used in the preparation of aminosulfuranes with N-heterocyclic groups.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 67-56-1 methanol 
• 7318-81-2 bis(methoxy)methylborane 
• 172617-53-7 pyridinium N-(5'-chloropyridin-2'-yl)aminide 
• 111098-22-7 2-<(benzotriazol-1-yl)methylamino>-5-chloropyridine 

Downstream Products

• 1428241-44-4 C₁₉H₁₈ClN₅O₂ 
• 1586822-30-1 3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)benzoic acid 
• 868636-63-9 methyl 5-chloro-2-{[(5-chloropyridin-2-yl)(methyl)amino]methyl}benzoate 

Relevant articles and documents

Iridium-catalyzed enantioselective addition of an: N -methyl C-H bond to α-trifluoromethylstyrenes via C-H activation

The Ir-catalyzed enantioselective addition of an N-methyl C-H bond of 2-(methylamino)pyridine derivatives to α-trifluoromethylstyrenes proceeded via C-H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C-H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex.

BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE

Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.

The Chemistry of N-Substituted Benzotriazoles. Part 4. A Novel and Versatile Method for the Mono-N-alkylation of Aromatic and Heteroaromatic Amines

Mono-N-alkylation of aromatic and heteroaromatic amines is achieved in high yield by NaBH4 reduction of the adducts formed from benzotriazole, aliphatic aldehydes and the amines.Reaction of the same adducts with Grignard reagents gives N-(secondary alkyl)arylamines.Carboxy groups need no protection and nitro groups are unaffected.Adenine is mono-N-alkylated in high yield.