4214-80-6

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Chloro-N-methylpyridin-2-amine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be further functionalized and incorporated into complex molecular structures. Its presence in the molecule can contribute to the biological activity and pharmacological properties of the final drug product.
Used in Agrochemical Development:
In the agrochemical industry, 5-chloro-N-methylpyridin-2-amine is utilized as a building block for the development of new pesticides and herbicides. Its unique structure allows for the creation of compounds with specific target pest profiles and improved environmental safety.
Used in the Preparation of Aminosulfuranes:
5-Chloro-N-methylpyridin-2-amine is used in the preparation of aminosulfuranes with N-heterocyclic groups. These aminosulfuranes are valuable for their potential applications in various chemical reactions and processes, including the synthesis of novel sulfur-containing compounds with potential applications in materials science and medicinal chemistry.
Overall, 5-chloro-N-methylpyridin-2-amine is a versatile and important compound in the fields of pharmaceuticals, agrochemicals, and materials science, serving as a key intermediate in the development of new and improved products.

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 67-56-1 methanol 
• 7318-81-2 bis(methoxy)methylborane 
• 111098-22-7 2-<(benzotriazol-1-yl)methylamino>-5-chloropyridine 
• 172617-53-7 pyridinium N-(5'-chloropyridin-2'-yl)aminide 

Downstream Products

• 868636-63-9 methyl 5-chloro-2-{[(5-chloropyridin-2-yl)(methyl)amino]methyl}benzoate 
• 1586822-30-1 3-(N-(5-chloropyridin-2-yl)-N-methylsulfamoyl)benzoic acid 
• 1428241-44-4 C₁₉H₁₈ClN₅O₂ 

Relevant academic research and scientific papers

Iridium-catalyzed enantioselective addition of an: N -methyl C-H bond to α-trifluoromethylstyrenes via C-H activation

The Ir-catalyzed enantioselective addition of an N-methyl C-H bond of 2-(methylamino)pyridine derivatives to α-trifluoromethylstyrenes proceeded via C-H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C-H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex.

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease, such as malaria, caused by a Plasmodium parasite.

BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE

Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.

Pyridinium N-,(2'-azinyl)aminides: Regioselective synthesis of 2- alkylaminoazines

The regioselective alkylation of pyridinium-N-(2f'-azinil)aminides with alkyl halides under mild conditions is described. The alkylation, combined with a reduction of the N-N bond, allows an easy preparation of 2- alkylaminoazines. (C) 2000 Elsevier Science Ltd.

The Chemistry of N-Substituted Benzotriazoles. Part 4. A Novel and Versatile Method for the Mono-N-alkylation of Aromatic and Heteroaromatic Amines

Mono-N-alkylation of aromatic and heteroaromatic amines is achieved in high yield by NaBH4 reduction of the adducts formed from benzotriazole, aliphatic aldehydes and the amines.Reaction of the same adducts with Grignard reagents gives N-(secondary alkyl)arylamines.Carboxy groups need no protection and nitro groups are unaffected.Adenine is mono-N-alkylated in high yield.