42152-99-8Relevant academic research and scientific papers
A NOVEL SYNTHETIC PATHWAY TOWARDS SOLITHROMYCIN AND PURIFICATION THEREOF
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Page/Page column 22, (2017/08/01)
The present invention relates to an efficient route of synthesis of solithromycin and to a method of its purification which obviates the necessity of chromatographic purifications and improves the quality of the product by efficiently removing impurities.
Metal-free C-N cross-coupling of electrophilic compounds and N-haloimides
Zhang, Luyan,Li, Yanru,Jin, Long-Yi,Liang, Fushun
, p. 65600 - 65603 (2015/08/18)
When DBU is added, the cross-coupling reaction between alkyl halides (halogen = Cl, Br and I) and N-haloimides (halogen = Cl, Br) occurs, resulting in the formation of aminated products. A halogen bond activated nucleophilic substitution mechanism was proposed. The methodology represents an elegant example of applying the halogen bond activation strategy in an organic transformation.
Identification of a gene cluster that directs putrebactin biosynthesis in Shewanella species: PubC catalyzes cyclodimerization of N-Hydroxy-N- succinylputrescine
Kadi, Nadia,Arbache, Simon,Song, Lijiang,Oves-Costales, Daniel,Challis, Gregory L.
supporting information; experimental part, p. 10458 - 10459 (2009/02/05)
Putrebactin is a dihydroxamate iron chelator produced by the metabolically versatile marine bacterium Shewanella putrefaciens. It is a macrocyclic dimer of N-hydroxy-N-succinyl-putrescine (HSP) and is structurally related to desferrioxamine E, which is a
Adenine derivatives and their use as agents for increasing yield of crops
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, (2008/06/13)
Disclosed are novel adenine derivatives represented by the formula I and agriculturally acceptable acid addition salts thereof represented by the formula: STR1 wherein n is an integer of 2-4. Compositions for increasing yield of crops such as leguminous crops and gramineous crops which contain the above adenine derivatives or salts thereof as an active ingredient and methods for increasing yield of crops using these compositions are also disclosed.
Tests of a Piperidino Mask for the Protection of Functionalized Carbon Sites in Multistep Syntheses
Olofson, R. A.,Abbott, Duain E.
, p. 2795 - 2799 (2007/10/02)
Primary alkyl chlorides (R-Cl) are easily isolated in excellent yield after treatment of the appropriate N-alkylpiperidines (R-NC5H10) with α-chloroethyl chloroformate.The method is exemplified by the conversion of a variety of alkylpiperidines, including systems with other sensitive functionalities, to the respective chlorides in yields varying from 90 to 97percent.The potential significance of this process in drug congener preparation and in total synthesis is outlined.Similar fragmentations of N-sec-alkylpiperidines are described.
