42203-03-2

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-Pyridinyl)-1-hexanone is used as a precursor in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows it to be a key component in the production of both legal medications and illicit substances.
Used in Organic Synthesis:
In the field of organic chemistry, 1-(2-Pyridinyl)-1-hexanone serves as a valuable reagent. Its properties make it suitable for use in a range of chemical reactions, contributing to the synthesis of complex organic compounds.
Used in the Food Industry:
1-(2-Pyridinyl)-1-hexanone is utilized as a flavoring agent in the food industry. Its pleasant odor and ability to impart specific tastes make it a useful component in creating a variety of flavors for food products.
Used in Illicit Drug Production:
Regrettably, 1-(2-Pyridinyl)-1-hexanone is also known for its use in the illicit production of drugs such as methamphetamine and MDMA. Its role in these processes is a testament to its chemical versatility, albeit in an undesirable context.

InChI:InChI=1/C11H15NO/c1-2-3-4-8-11(13)10-7-5-6-9-12-10/h5-7,9H,2-4,8H2,1H3

Upstream product

• 100-70-9 2-Cyanopyridine 
• 693-25-4 n-pentylmagnesium bromide 
• 110-53-2 1-Bromopentane 
• 1121-60-4 pyridine-2-carbaldehyde 
• 109-67-1 1-penten 
• 2524-52-9 ethyl-2-picolinate 
• 23708-48-7 pentamethylenebis(magnesium bromide) 

Relevant academic research and scientific papers

Engineering an iridium-containing metal-organic molecular capsule for induced-fit geometrical conversion and dual catalysis

By introducing photoactive fac-tris(2-phenylpyridine)iridium moieties as a ligand backbone to constrain the coordination geometry of cobalt ions, a multifunctional Ir2Co3-type capsule was achieved and showed induced-fit capsule-capsule conversion by cooperative binding one carbonate anion with the equatorial Co(ii) centers. The capsule combined photocatalysis and transition metal activation synergistically and exhibited efficient catalytic ability on visible light-activated α-trichloromethylation.

Rhodium Catalyzed Asymmetric Hydrogenation of 2-Pyridine Ketones

Catalyzed by [Rh(COD)Binapine]BF4, the asymmetric hydrogenation of 2-pyridine ketones has been achieved with excellent enantioselectivities (enantiomeric excesses up to 99%) under mild conditions. This method is suitable for various kinds of 2-pyridine ketones and their derivatives. A number of enantiomerically pure chiral 2-pyridine-aryl/alkyl alcohols were prepared through hydrogenation, which can be used directly in organic synthesis.

Exploring isonitrile-based click chemistry for ligation with biomolecules

We show here that isonitriles can perform click reactions with tetrazines in aqueous media, making them promising candidates for ligation reactions in chemical biology and polymer chemistry. This is the first time that a [4+1] cycloaddition has been used as a biocompatible ligation reaction.

Aerobic oxidation of secondary benzylic alcohols and direct oxidative amidation of aryl aldehydes promoted by sodium hydride

We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.

Hydroacylation of 1-alkene with heteroaromatic aldehyde by Rh(I) and additives

Hydroacylation of 1-alkene with a heteroaromatic aldehyde such as pyridinecarboxaldehyde, thiophenecarboxaldehyde and furfural derivatives under cocatalyst of Wilkinson's complex and 2-amino-3-picoline gave poor yield of hydroacylated product. The addition of a catalytic amount of bis(cyclopentadienyl)zirconium dichloride or bis(cyclopentadienyl)titanium dichloride as an additive dramatically increased the yield of the hydroacylated ketone product.

STERIC EFFECTS IN THE REACTION OF DI(BROMOMAGNESIO)ALKANES WITH CARBOXYLIC ESTERS

Largely different product distributions were observed on the action of various carboxylic esters with 1,4-di(bromomagnesio)butane and its homologue 1,5-di(bromomagnesio)pentane.The much larger yields of reduction product with the latter are the evidence for the structural geometric requirements for the annelation step.