42203-37-2

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule of the compound.

Explanation

The compound is commonly used as a building block for the synthesis of various pharmaceuticals and agrochemicals.

Explanation

The compound appears as a white solid at room temperature.

Explanation

The molecular weight is the mass of one mole of the compound, which is the sum of the atomic weights of all the atoms in the molecule.

Explanation

The melting point is the temperature range at which the compound transitions from a solid to a liquid state.

Explanation

The compound is primarily used in the production of pharmaceutical drugs but can also be utilized in the manufacturing of various other organic compounds.

Explanation

The compound is known to have moderate toxicity, which means it can cause harm if not handled properly.

Explanation

Due to its moderate toxicity, it is essential to take necessary safety measures when handling 1-bromo-4-(4-methoxyphenoxy)benzene.

Brominated derivative

4-(4-methoxyphenoxy)benzene

Usage

Organic synthesis and medicinal chemistry

Physical state

White solid

Molecular weight

273.13 g/mol

Melting point

70-72°C

Applications

Pharmaceutical drugs, polymers, dyes, and other organic compounds

Toxicity

Moderate

Safety precautions

Handle with care

Upstream product

• 75-15-0 carbon disulfide 
• 1655-69-2 1-methoxy-4-phenoxy-benzene 
• 7664-93-9 sulfuric acid 
• 106-37-6 1.4-dibromobenzene 
• 150-76-5 4-methoxy-phenol 
• 106-41-2 4-bromo-phenol 
• 696-62-8 para-iodoanisole 
• 623-12-1 4-chloromethoxybenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 100-66-3 methoxybenzene 
• 13320-48-4 4-hydroxy-4'-bromodiphenyl ether 
• 74-88-4 methyl iodide 

Downstream Products

• 16236-35-4 4-(4-(4-phenoxy)phenoxy)phenoxyphenol 
• 620632-57-7 4-(4-methoxyphenoxy)benzene boronic acid 
• 78563-40-3 1,4-bis(p-methoxyphenoxyl)benzene 
• 15051-26-0 4,4'-(1,4-phenylenebis(oxy)) diphenol 

Relevant academic research and scientific papers

Dihydropyrimidine compound and uses of dihydropyrimidine compound in drugs

The present invention relates to a dihydropyrimidine compound and uses of the dihydropyrimidine compound as drugs, particularly as drugs for treatment and prevention of hepatitis B, particularly to acompound represented by a general formula (I) or (Ia) or an enantiomer, a diastereomer, a tautomer, a hydrate, a solvate or a pharmaceutically acceptable salt thereof, wherein each variable is definedin the specification. The invention further relates to uses of the compound represented by a general formula (I) or (Ia) or the enantiomer, the diastereomer, the tautomer, the hydrate, the solvate orthe pharmaceutically acceptable salt thereof as drugs, especially as drugs for treatment and prevention of hepatitis B. The formulas (I) and (Ia) are defined in the specification.

DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE

Provided herein are a dihydropyrimidine compound and a pharmaceutical application thereof, especially the application used for treating and preventing HBV diseases. Specifically, provided herein is a compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is use of the compound having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof as a medicine, especially for treating and preventing HBV diseases.

Cu(I)-PNF, an organic-based nanocatalyst, catalyzed C-O and C-S cross-coupling reactions

Peptide nanofiber has been prepared via a self-assembly protocol and decorated with Cu(I) to prepare a nanostructural catalyst. The catalytic activity of this prepared nanomaterial (Cu(I)-PNF) was examined in C-O and C-S cross-coupling reactions. Compared with conventional copper-ligand catalytic systems, CuNP-PNF has unique advantages such as water solubility, high efficiency, and low cost, which makes it a highly efficient and beneficial catalyst to reuse in cross-coupling reactions.

SUBSTITUTED AMINOALKYLAZOLES AS MALARIAL ASPARTIC PROTEASE INHIBITORS

The present invention relates to novel aminoalkylazoles acting as inhibitors of malarial protease plasmepsin II. These can be used as medicines or as constituent of medicines for the treatment of malaria infection.

Para-Selective Cu-Catalyzed C-H Aryloxylation of Electron-Rich Arenes and Heteroarenes

Cu-catalyzed reaction of phenols with electron-rich arene or heteroarene ligands of unsymmetrical diaryl-λ3-iodanes is a key step in the developed one-pot two-step method for intermolecular para-selective C-H aryloxylation of heteroarenes and arenes.

Copper and l-sodium ascorbate catalyzed hydroxylation and aryloxylation of aryl halides

CuSO4·5H2O and NaAsc catalyzed hydroxylation and C-O/C-S cross-coupling reactions of aryl halides with phenols or 4-methylbenzenethiol were described. A wide range of substrates and test cases highlight the synthetic utility of the approach. A series of phenols, diaryl ethers, alkylaryl ethers, and diaryl thioethers were synthesized in high yield.

Fe3O4@mesoporouspolyaniline: A highly efficient and magnetically separable catalyst for cross-coupling of aryl chlorides and phenols

A high surface, magnetic Fe3O4@mesoporouspolyaniline core-shell nanocomposite was synthesized from magnetic iron oxide (Fe 3O4) nanoparticles and mesoporouspolyaniline (mPANI). The novel porous magnetic Fe3O4 was obtained by solvothermal method under sealed pressure reactor at high temperature to achieve high surface area. The mesoporouspolyaniline shell was synthesized by in situ surface polymerization onto porous magnetic Fe3O4 in the presence of polyvinylpyrrolidone (PVP) and sodium dodecylbenzenesulfonate (SDBS), as a linker and structure-directing agent, through 'blackberry nanostructures' assembly. The material composition, stoichiometric ratio and reaction conditions play vital roles in the synthesis of these nanostructures as confirmed by variety of characterization techniques. The role of the mesoporouspolyaniline shell is to stabilize the porous magnetic Fe3O4 nanoparticles, and provide direct access to the core Fe3O4 nanoparticles. The catalytic activity of magnetic Fe3O 4@mesoporousPANI nanocomposite was evaluated in the cross-coupling of aryl chlorides and phenols. Copyright

CuI nanoparticles for C-N and C-O cross coupling of heterocyclic amines and phenols with chlorobenzenes

(Chemical Equation Presented) Employing CuI nanoparticles as an efficient catalyst for the cross-coupling reactions of various N/O nucleophilic reagents with aryl chlorides could be successfully carried out under mild conditions in the absence of both the ligands and strong bases. A variety of products including N-arylimidazoles and aryl ethers were synthesized in good to excellent yields. 2009 American Chemical Society.

Efficient catalytic activity of copper/aluminum hydrotalcite in diaryl ether synthesis

A simple copper/aluminum hydrotalcite (Cu/Al-HT) catalyzed arylation of phenols with aryl iodides afforded the corresponding diaryl ethers in moderate to excellent yields. This ligand- free Cu/Al-HT catalyzed coupling of aryl iodides with phenols resulted in high yields of diaryl ethers in the absence of an additive. The catalyst was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles. Georg Thieme Verlag Stuttgart New York.

Highly efficient copper-catalyzed O-arylation using readily available (S)-N-methylpyrrolidine-2-carboxamide as the ligand

A highly efficient and readily available catalyst system for O-arylation of various phenols using CuI and (S)-N-methylpyrrolidine-2-carboxamide (Pro-NHMe) was developed. The reaction is widely applicable to the synthesis of diaryl ethers. Georg Thieme Verlag Stuttgart.