13320-48-4

Basic information

• Product Name: 4-(4-BROMOPHENOXY)PHENOL
• Synonyms: 4-(4-BROMOPHENOXY)PHENOL;4-(4-Bromophenyloxy)phenol;4-(4-Bromophenoxy)phenol 97%
• CAS NO: 13320-48-4
• Molecular Formula: C₁₂H₉BrO₂
• Molecular Weight: 265.1
• Product Categories: Organic Building Blocks;Oxygen Compounds;Phenols;Building Blocks;C9 to C20+;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 13320-48-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 73-78 °C
• Boiling Point: 359.5°C at 760 mmHg
• Flash Point: 171.2°C
• Appearance: /
• Density: 1.518g/cm³
• Vapor Pressure: 1.15E-05mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: 2-8°C
• PKA: 9.92±0.15(Predicted)
• CAS DataBase Reference: 4-(4-BROMOPHENOXY)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BROMOPHENOXY)PHENOL(13320-48-4)
• EPA Substance Registry System: 4-(4-BROMOPHENOXY)PHENOL(13320-48-4)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36-43-51/53
• Safety Statements: 26-36/37-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 13320-48-4(Hazardous Substances Data)

Usage

General Description

4-(4-Bromophenoxy)phenol is a chemical compound with the molecular formula C12H9BrO2. It is a white crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-(4-BROMOPHENOXY)PHENOL is also used as an intermediate in the manufacture of dyes and pigments. It is known to have potential health hazards, including skin and eye irritation, and should be handled with care. 4-(4-Bromophenoxy)phenol may also be used as a research chemical in various scientific studies.

InChI:InChI=1/C12H9BrO2/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8,14H

Upstream product

• 31465-35-7 4-(4-bromophenoxy)aniline 
• 350-46-9 4-Fluoronitrobenzene 
• 21969-04-0 1-(4-nitrophenoxy)-4-bromobenzene 
• 69240-56-8 4-(4-bromophenoxy)benzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 106-41-2 4-bromo-phenol 
• 123-31-9 hydroquinone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 10035-10-6 hydrogen bromide 
• 27721-64-8 4-(4-Bromo-phenoxy)-2,4,6-tri-tert-butyl-cyclohexa-2,5-dienone 
• 20185-64-2 4-(4-bromophenoxy)phenyl acetate 

Downstream Products

• 42203-37-2 1-bromo-4-(4-methoxyphenoxy)benzene 
• 1256264-21-7 1-(2-(4-(4-bromophenoxy)phenoxy)ethyl)pyrrolidine 
• 52299-46-4 D-2-[p-(p-bromophenoxy)phenoxy]-propionic acid 
• 52299-48-6 2-[4-(4-Bromo-phenoxy)-phenoxy]-propionic acid ethyl ester 
• 51338-14-8 [4-(4-Bromo-phenoxy)-phenoxy]-acetic acid 
• 52299-51-1 2-[4-(4-Bromo-phenoxy)-phenoxy]-propionic acid butyl ester 
• 52299-52-2 2-[4-(4-Bromo-phenoxy)-phenoxy]-propionic acid isobutyl ester 
• 52299-49-7 2-[4-(4-Bromo-phenoxy)-phenoxy]-propionic acid propyl ester 
• 52299-50-0 2-[4-(4-Bromo-phenoxy)-phenoxy]-propionic acid isopropyl ester 
• 52299-47-5 2-[4-(4-Bromo-phenoxy)-phenoxy]-propionic acid methyl ester 

Relevant articles and documents

Method for selectively preparing hydroquinone monoether compound or quinol compound (by machine translation)

The method comprises the following steps: taking an organic boric acid compound and a p-benzoquinone compound as a reaction raw material, under the action of a copper catalyst, selectively reacting to obtain a hydroquinone monoether compound or a quinol compound. Compared with the prior art, the method disclosed by the invention adopts a one-pot reaction, can selectively obtain two products through solvent control, is suitable for preparing various types of hydroquinone monoether compounds and quinol compounds, and has wide applicability. The substrate functional group is high in tolerance and wide in substrate range. The raw material and the catalyst are cheap and easily available, the reaction conditions are mild, the reaction solvent is green and environment-friendly, the post-treatment is simple, and the yield and purity of the product are high. The preparation method is convenient. The method is rapid and efficient, and has a good application prospect in drug molecule synthesis. (by machine translation)

HETEROARYL COMPOUNDS AND THEIR USE AS MER INHIBITORS

Compounds of formula (I) [Formula should be inserted here] and a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, R4, R5, R6, R7, R24, X, L, n and p are as defined in the specification, are useful for treating or preventing Mer tyrosine kinase receptor modulated disease or conditions. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

A convenient method for the preparation of 4-aryloxyphenols

A convenient method for the preparation of 4-aryloxyphenols via the homologation of preformed phenols is described. Condensation of various 4-substituted phenols with either 4-fluorobenzaldehyde (8) or 4-fluoroacetophenone (9) yielded the corresponding 4-aryl-oxybenzaldehydes, 10, and acetophenones, 11, in 70-93% yield. Baeyer-Villiger oxidation of these materials with 3-chloroperoxybenzoic acid (MCPBA) yielded the corresponding 4-formyloxy and 4-acetoxyphenyl ethers which were hydrolyzed without purification to the desired 4-aryloxyphenols 12 in 72-94% yield. Both 4-fluorobenzaldehyde (8) and 4-fluoroacetophenone (9) are synthetically equivalent to the a4 umpoled synthon 6. Extension of this methodology of the preparation of 4,4'-[arylbis(oxy)]bisphenols from aromatic diols is also described. Condensation of various aromatic diols with 8 or 9 yielded the corresponding 4,4'-[arylbis(oxy)]bisbenzaldehydes 15 and acetophenones 16 in 71-89% yield. Baeyer-Villiger oxidation of these compounds with MCPBA yielded the desired 4,4'-[arylbis(oxy)]bisphenyl bisformates 17 and bisacetates 18 in 67-84% yield. Hydrolysis of these compounds afforded the desired 4,4'-[arylbis(oxy)bisphenols 19 in 70-91% yield.