26348-47-0

Basic information

• Product Name: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (2Z)-
• CAS NO: 26348-47-0
• Molecular Formula: C16H13NO3
• Molecular Weight: 267.284
• Mol File: 26348-47-0.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (2Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (2Z)-(26348-47-0)
• EPA Substance Registry System: 2-Propenoic acid, 2-(benzoylamino)-3-phenyl-, (2Z)-(26348-47-0)

Safety Data

• Hazardous Substances Data: 26348-47-0(Hazardous Substances Data)

Usage

Also known as

(Z)-N-(3-carboxy-1-oxo-2-propen-1-yl)-D-phenylalanine
Belongs to the class of compounds known as phenylpropanoic acids
Used in the pharmaceutical industry for drug synthesis
Used in research applications as a chemical building block
Potential biological activity
Studied for its ability to inhibit certain enzymes and receptors in the body

Upstream product

• 101-84-8 diphenylether 
• 17606-70-1 (4Z)-4-benzylidene-2-phenyl-1,3-oxazol-5(4H)-one 
• 60-29-7 diethyl ether 
• 495-69-2 Hippuric Acid 
• 100-52-7 benzaldehyde 
• 42267-16-3 threo-DL-β-phenylserine ethyl ester hydrochloride 
• 64951-87-7 (2RS,3SR)-2-benzoylamino-3-hydroxy-3-phenyl-propionic acid ethyl ester 
• 842-74-0 4-benzylidene-2-phenyloxazole-5(4H)-one 
• 150-78-7 1,4-dimethoxybezene 
• 26348-46-9 (Z)-ethyl 2-benzamido-3-phenylacrylate 
• 27573-05-3 methyl ester of benzoylaminocinnamic acid 
• 57427-85-7 (E)-α-(benzamido)-cinnamic acid 
• 2566-22-5 N-benzoyl-L-phenylalanine 

Downstream Products

• 79965-45-0 N-(N-benzoyldehydrophenylalanyl)-(S)-valine methyl ester 
• 75179-48-5 (S)-((Z)-2-Benzoylamino-3-phenyl-acryloylamino)-phenyl-acetic acid methyl ester 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 37002-52-1 N-benzoyl-D-phenylalanine 
• 2566-22-5 DL-N-benzoylphenylalanine 
• 2566-22-5 N-benzoyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 21462-02-2 methyl (Z)-2-benzoylamino-3-phenyl-2-propenoate 
• 88152-84-5 bis(diphenylphosphinomethyl)dioxolane rhodium(I)(C₆H₅CONHCCHC₆H₅CO₂) 
• 32089-78-4 ethyl 2-(benzoylamino)-3-(phenyl)acrylate 
• 1155-48-2 2-benzoylaminocinnamic acid 
• 79965-48-3 Bz-D-Phe-L-Val-OMe 
• 74863-35-7 Bz-L-Phe-L-Val-OMe 

Relevant articles and documents

Synthesis of oxazoles from enamides via phenyliodine diacetate-mediated intramolecular oxidative cyclization

A group of functionalized oxazoles were synthesized in moderate to good yields from enamides via phenyliodine diacetate (PIDA)-mediated intramolecular cyclization. The main advantageous features of the present method include its broad substrate scope and the heavy-metal-free characteristic of the oxidative carbon-oxygen bond formation process.

Kinetics and mechanism of the nucleophilic ring opening of oxazolinone in mixed aqueous solvents

Solvent effect on the kinetics of ring opening of oxazolinone has been investigated in neutral and alkaline medium in dioxan-water mixtures up to 50% v/v in the temperature range of 40-60°C. The thermodynamic activation parameters have been calculated and discussed in terms of solvation effect. The isokinetic temperature in both media (310, 303 and 298 K for neutral, alkaline hydrolysis by NaOH and Na2CO3 respectively) indicates that the reaction is entropy controlled and that solute-solvent interactions play an important role. The correlation of logk2 against either Grunwald-Wientien Y values or log[H2O] Is found to be linear, while the correlation between logk2 and the reciprocal of the dielectric constant is nonlinear. The estimated value of the slope m in Grunwald relationship gives a value less than unity indicating SAN/SN2 mechanism. Mechanism for the oxazolinone ring opening has been proposed.

An usual behaviour of ethers in presence of azlactones under ultrasound irradiation to give esters

The phenomenon of ester formation from ethers and azlactones under sonolysis has been observed.