423-53-0

Basic information

• Product Name: 1-CHLORO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-HEXADECAFLUOROOCTANE
• Synonyms: 1-CHLORO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-HEXADECAFLUOROOCTANE;8-CHLORO-1H-PERFLUOROOCTANE;1-Chloro-8H-perfluorooctane
• CAS NO: 423-53-0
• Molecular Formula: C₈HClF₁₆
• Molecular Weight: 436.52
• Mol File: 423-53-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 178°C
• Flash Point: 72.2°C
• Appearance: /
• Density: 1.679g/cm³
• Vapor Pressure: 4.75mmHg at 25°C
• Refractive Index: 1.284
• CAS DataBase Reference: 1-CHLORO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-HEXADECAFLUOROOCTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-HEXADECAFLUOROOCTANE(423-53-0)
• EPA Substance Registry System: 1-CHLORO-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-HEXADECAFLUOROOCTANE(423-53-0)

Safety Data

• Safety Statements: 23-24/25
• Hazardous Substances Data: 423-53-0(Hazardous Substances Data)

Usage

General Description

1-Chloro-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-hexadecafluorooctane, also known as perfluorooctyl chloride, is a fluorinated organic compound with the chemical formula C8ClF16. It is a colorless, odorless liquid with a high boiling point and low reactivity. The chemical is used in a variety of industrial applications, including as a solvent, surfactant, and as a building block in the production of fluorinated polymers. It is also used in the production of firefighting foams and in the manufacturing of electronic components. However, the chemical is a persistent organic pollutant and has been found to have adverse effects on human health and the environment, leading to restrictions and regulations on its use in some countries.

InChI:InChI=1/C8HClF16/c9-8(24,25)7(22,23)6(20,21)5(18,19)4(16,17)3(14,15)2(12,13)1(10)11/h1H

Upstream product

• 16486-98-9 1-chloro-1H,8H-hexadecafluoro-8-iodo-octane 
• 121-44-8 triethylamine 
• 140-88-5 ethyl acrylate 
• 68-12-2 N,N-dimethyl-formamide 
• 107-13-1 acrylonitrile 
• 78-94-4 methyl vinyl ketone 
• 97-63-2 methyl methacrylate 
• 10544-63-5 ethyl crotonate 
• 76-21-1 9H-hexadecafluorononanoic acid 
• 75-45-6 Chlorodifluoromethane 

Downstream Products

• 335-65-9 hydroperfluorooctane 
• 307-34-6 Perfluorooctane 
• 307-99-3 1H,8H-perfluorooctane 
• 307-33-5 1-Chloroperfluorooctane 

Relevant articles and documents

A novel synthesis of per(poly)fluoroalkyl aldehydes

A novel synthesis of per(poly)fluoroalkyl aldehydes in high yield by the reaction of per(poly)fluoroalkyl iodides or bromides with dimethylformamide initiated by a PbBr2(catalyst)/Al bimetal redox system is described.

Nickel-, Palladium-, and Platinum-Catalyzed Reactions of Perfluoro- and Polyfluoroalkyl Iodides with Tertiary Amines

The relative catalytic activities of Ni group metals in the reactions of perfluoroalkyl and polyfluoroalkyl iodides with tertiary amines to give enamines were compared, giving a reactivity order Ni > Pd > Pt, which parallels the order of the first ionization potential of the three metals.In comparing the Ni-catalyzed reaction of iodide 1 with tertiary amines containing zero to three methyl groups, it was found that in the case of trimethylamine only the reduced product 4 was formed, while the other three types of tertiary amines produced enamines (19, 21, 23) as wellas 4.The chemoselectivity of this reaction was studied.A mechanism is proposed for the reaction.Acid hydrolysis of (fluoroalkyl)enamines afforded enaminones or aldehydes depending upon the presence or absence of an alkyl group at the β-carbon.