42331-15-7

Usage

Uses

Used in Pharmaceutical Research:
Delta-aminobenzenebutanol is used as a research chemical for studying its psychoactive properties and potential therapeutic effects on psychiatric and neurological disorders. Its structural similarity to methaqualone allows researchers to explore its mechanisms of action and compare its efficacy with existing sedative-hypnotic drugs.
Used in Drug Development:
Although not approved for medical use, delta-aminobenzenebutanol is used in the development of new drugs targeting psychiatric and neurological disorders. Its potential applications in treating various conditions make it a valuable compound for drug discovery and development efforts.
Used in Controlled Substance Regulation:
Due to its psychoactive properties and potential for abuse, delta-aminobenzenebutanol is used as a reference compound in the regulation and control of substances with similar effects. Its classification as a controlled substance helps inform policies and guidelines for the management of psychoactive drugs in many countries.

Upstream product

• 39755-03-8 4-hydroxy-1-phenyl-butan-1-one 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 109-99-9 tetrahydrofuran 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 100-58-3 phenylmagnesium bromide 
• 100-47-0 benzonitrile 
• 1730-25-2 allylmagnesium bromide 
• 107045-41-0 3-Benzoylpropionic Acid,O-Methyloxime 

Downstream Products

• 42331-01-1 4-chloro-1-phenyl-butylamine 
• 1006-64-0 2-(phenyl)pyrrolidine 

Relevant academic research and scientific papers

N-Hydroxyphthalimide-catalyzed chemoselective intermolecular benzylic C-H amination of unprotected arylalkanols

N-Hydroxyphthalimide-catalyzed chemoselective benzylic C(sp3)-H amination of unprotected arylalkanols using bis(2,2,2-trichloroethyl)azodicarboxylate has been developed. The use of 1,1,1,3,3,3-hexafluoropropan-2-ol as a solvent plays a critical role in chemoselectivity. The conversion of an aminated product to the corresponding free amino alcohol was also demonstrated.

Synthesis of 1,4-amino alcohols by Grignard reagent addition to THF and N-tosyliminobenzyliodinane

The synthesis of 1,4-amino alcohols from THF treated with N-tosyliminobenzyliodinane (PhINTs) followed by a Grignard reagent under mild reaction conditions at room temperature is described herein. Various Grignard reagents were shown to be compatible, furnishing the corresponding 4-substituted-N-1,4-tosylamino alcohols in good to excellent yields. A partial or full detosylation of the N-tosyl-1,4-amino alcohol was observed in instances involving a sterically bulky Grignard reagent, leading to the deprotected 1,4-amino alcohol product in moderate to good yields. The synthetic utility of this protocol was demonstrated by the synthesis of a 5-substituted-N-tosyl-1,5-amino alcohol from THP and the conversion of two examples to their corresponding γ-lactam and pyrrolidine adducts.

Synthesis of 2-substituted pyrrolidines from nitriles

A novel and synthetically facile production of 2-substituted pyrrolidines from commercially available nitriles is reported herein. This methodology is operationally simple, and only requires the use of an extraction and a single chromatographic purificati

Phosphinylalkanoyl imino acids

Phosphinylalkanoyl imino acids useful in the treatment of hypertension are disclosed.