42351-88-2

Usage

Uses

Used in Organic Synthesis:
2-tert-butylpyrimidin-4(1H)-one is utilized as a key intermediate in the synthesis of various organic compounds, particularly those with potential applications in pharmaceuticals and agrochemicals. Its unique structure allows for the formation of diverse derivatives, expanding the scope of chemical reactions and product development.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-tert-butylpyrimidin-4(1H)-one is employed as a building block for the synthesis of biologically active molecules. Its incorporation into drug candidates can enhance their pharmacological properties, such as potency, selectivity, and bioavailability, leading to the development of novel therapeutic agents.
Used in Drug Discovery and Development:
2-tert-butylpyriMidin-4(1H)-one's potential pharmacological properties make it an attractive target for drug discovery and development. Researchers are investigating its interactions with biological targets, such as enzymes and receptors, to identify potential therapeutic applications in various disease areas.
Used in the Agricultural Industry:
2-tert-butylpyrimidin-4(1H)-one has been studied for its potential applications as a pesticide or herbicide in the agricultural industry. Its ability to target specific pests or weeds could lead to the development of more effective and environmentally friendly crop protection solutions.

InChI:InChI=1/C8H12N2O/c1-8(2,3)7-9-5-4-6(11)10-7/h4-5H,1-3H3,(H,9,10,11)

Upstream product

• 59950-56-0 pivalimidamide 
• 61319-99-1 2-tert-butylpyrimidine 
• 91167-21-4 5-chloro-2-(1,1-dimethylethyl)pyrimidine 
• 18202-73-8 pivalamidine hydrochloride 
• 85929-94-8 5-Bromo-2-(1,1-dimethylethyl)pyrimidine 

Downstream Products

• 140201-04-3 2-t-butyl-4-methoxypyrimidine 
• 140201-05-4 2-t-butyl-3-methylpyrimidin-4(3H)-one 
• 70227-51-9 4-amino-5-nitro-2-t-butylpyrimidine 
• 112381-86-9 5-benzylideneamino-4-benzylidenehydrazino-2-t-butylpyrimidine 
• 112381-85-8 4-benzylidenehydrazino-5-nitro-2-t-butylpyrimidine 
• 112381-83-6 1-benzylideneamino-5-t-butyl-1H-v-triazolo<4,5-d>pyrimidine 
• 70227-50-8 4-chloro-5-nitro-2-t-butylpyrimidine 

Relevant academic research and scientific papers

Heterocyclic Compounds Useful as RAF Kinase Inhibitors

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

SYNTHESIS OF 2-t-BUTYL-5-HYDROXYPYRIMIDINE VIA HYDROLYSIS OF 2-t-BUTYL-5-HALOPYRIMIDINES

The hydrolysis of 2-t-butyl-5-halopyrimidine (halogen = bromine or chlorine) with sodium methoxide in methanol yields 2-t-butyl-5-hydroxypyrimidine.The side reaction product, 2-t-butylpyrimidine, is substantially reduced, especially in the case of the bromo derivative, with catalytic amounts of elemental sulfur.

Synthesis of 1- and 3-Amino-5-t-butyl-1H- and -3H-v-triazolopyrimidines as Hetaryne Precursors

The synthesis of the title compounds 6 and 8 has first been accomplished by reaction of O-mesitylsulfonylhydroxylamine with 5-t-butyl-3H-v-triazolopyrimidine (5) whose preparation is reported in detail.However the preferred route for the synthesis

Nucleophilic heteroaromatic substitution-XXIV. Kinetics of piperidinodechlorination of 2- and 6- alkyl-4-chloropyrimidines in ethanol and toluene-evidence for a steric hindrance to solvation of the aza-group

The rate constants for the reaction of 2- and 6-alkyl-4-chloropyrimidines with piperidine in toluene and ethanol have been determined at 30.0°. The reactivity ratio kMe/kt-Bu increases considerably in passing from the reaction of 6-alkyl-4-chloropyrimidines in toluene (1.62) to the reaction of 2-alkyl-4-chloropyrimidines in ethanol (17.3). This remarkable increase (over a factor of ten) is ascribed to a steric hindrance to solvation of the aza-groups caused by the bulkier substituent.