70227-51-9

Upstream product

• 18202-73-8 pivalamidine hydrochloride 
• 70227-49-5 2-tert-butyl-5-nitro-3H-pyrimidin-4-one 
• 42351-88-2 2-t-butyl-3,4-dihydro-4-oxopyrimidine 
• 70227-50-8 4-chloro-5-nitro-2-t-butylpyrimidine 

Downstream Products

• 112381-83-6 1-benzylideneamino-5-t-butyl-1H-v-triazolo<4,5-d>pyrimidine 

Relevant academic research and scientific papers

Heterocyclic Compounds Useful as RAF Kinase Inhibitors

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.

Synthesis of 1- and 3-Amino-5-t-butyl-1H- and -3H-v-triazolopyrimidines as Hetaryne Precursors

The synthesis of the title compounds 6 and 8 has first been accomplished by reaction of O-mesitylsulfonylhydroxylamine with 5-t-butyl-3H-v-triazolopyrimidine (5) whose preparation is reported in detail.However the preferred route for the synthesis