70227-50-8 Usage
Pyrimidine derivative
It is a compound derived from the pyrimidine core structure a heterocyclic aromatic organic compound that consists of a six-membered ring with four carbon atoms and two nitrogen atoms.
tert-Butyl group
The presence of a tert-butyl group (C4H9) in the compound, which is a type of alkyl group consisting of a methyl group attached to a secondary carbon atom.
Chlorine atom
The compound contains one chlorine atom (Cl), which is a halogen element that provides the compound with a negative charge.
Nitro group
The presence of a nitro group (-NO2) in the compound, which is a functional group consisting of an oxygen atom double-bonded to a nitrogen atom and a second oxygen atom single-bonded to the nitrogen atom.
Pharmaceutical and agricultural research applications
2-(tert-Butyl)-4-chloro-5-nitropyriMidine is used in the development of new drugs and pesticides due to its potential biological activity.
Yellow crystalline solid
The compound appears as a yellow-colored crystalline solid, which is a common physical form for many organic compounds.
Sparingly soluble in water
The compound does not dissolve easily in water, which is a characteristic of many organic compounds with nonpolar functional groups.
Soluble in organic solvents
2-(tert-Butyl)-4-chloro-5-nitropyriMidine dissolves well in organic solvents, such as ethanol, acetone, or dichloromethane, which are common solvents used in chemical research and laboratory work.
High chemical stability
The compound is known for its resistance to chemical reactions and degradation, making it suitable for long-term storage and use in research applications.
Relatively non-reactive under normal conditions
2-(tert-Butyl)-4-chloro-5-nitropyriMidine does not readily undergo chemical reactions or react with other substances under standard environmental conditions, contributing to its stability and safety in research settings.
Check Digit Verification of cas no
The CAS Registry Mumber 70227-50-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,2,2 and 7 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 70227-50:
(7*7)+(6*0)+(5*2)+(4*2)+(3*7)+(2*5)+(1*0)=98
98 % 10 = 8
So 70227-50-8 is a valid CAS Registry Number.
70227-50-8Relevant academic research and scientific papers
Heterocyclic Compounds Useful as RAF Kinase Inhibitors
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Page/Page column 45, (2009/01/24)
The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
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Page/Page column 89; 90, (2009/03/07)
The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.
PYRIDO PYRIMIDINONES, DIHYDRO PYRIMIDO PYRIMIDINONES AND PTERIDINONES USEFUL AS RAF KINASE INHIBITORS
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Page/Page column 104, (2010/11/08)
The present invention provides compounds having the formula: (I) wherein A-B together represents one of the following structures; (II), (III), (IV) and n, R1, R2, R3, R4, L1, L2, Y and Z are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as inhibitors of protein kinase (e.g., RAF), and thus are useful, for example, for the treatment of RAF mediated diseases.
Synthesis of 1- and 3-Amino-5-t-butyl-1H- and -3H-v-triazolopyrimidines as Hetaryne Precursors
Tielemans, Michel,Christophe, Daniel,Promel, Robert
, p. 705 - 708 (2007/10/02)
The synthesis of the title compounds 6 and 8 has first been accomplished by reaction of O-mesitylsulfonylhydroxylamine with 5-t-butyl-3H-v-triazolopyrimidine (5) whose preparation is reported in detail.However the preferred route for the synthesis
