42353-58-2

Upstream product

• 123-75-1 pyrrolidine 
• 501-65-5 diphenyl acetylene 
• 451-40-1 phenyl benzyl ketone 

Downstream Products

• 5533-73-3 4,5-Diphenyl-1H-[1,2,3]triazole 
• 88875-34-7 [1-Phenyl-1-pyrrolidin-1-yl-meth-(Z)-ylidene]-phosphoramidic acid diphenyl ester 
• 94191-34-1 [2,2-Diphenyl-1-pyrrolidin-1-yl-eth-(Z)-ylidene]-phosphoramidic acid diphenyl ester 
• 37928-17-9 5-methyl-3,4-diphenyl isoxazole 
• 181695-72-7 valdecoxib 
• 198470-84-7 parecoxib 
• 181696-73-1 3,4-diphenyl-4-hydrido-5-hydroxy-5-methylisoxazole 
• 720-43-4 2-fluoro-1,2-diphenylethanone 
• 365-01-5 2,2-difluoro-2-phenylacetophenone 
• 1779-91-5 1,2-diphenyl-2-(pyridin-2-yl)ethan-1-one 
• 95867-96-2 3,4,5-triphenyl-5-pyrrolidin-1-yl-4,5-dihydro-isoxazole 
• 55436-11-8 2-(dimethylaminothiocarbonylthio)desoxybenzoin 

Relevant academic research and scientific papers

A process for the preparation of sodium compound handkerchief auspicious past cloth and wherein the intermediate impurity, preparation method and application

The invention provides parecoxib sodium which is prepared by controlling an intermediate impurity and in particular provides a preparation method of a parecoxib sodium compound as well as the intermediate impurity and an application of the parecoxib sodium compound. According to the preparation method provided by the invention, 3-methyl-4,5-diphenyl-4,5-dihydro-isoxazole-5-alcohol is used as an isomer impurity for preparing 5-methyl-3,4-diphenyl-4,5-dihydro-isoxazole-5-alcohol as an intermediate of the parecoxib sodium, the quality of the 3-methyl-4,5-diphenyl-4,5-dihydro-isoxazole-5-alcohol is controlled in the preparation of the parecoxib sodium, specifically, the impurity content is required not to be higher than 0.5 percent, and an important significance is provided for the product quality of the parecoxib sodium; by obtaining the 3-methyl-4,5-diphenyl-4,5-dihydro-isoxazole-5-alcohol as an isomer impurity of the important 5-methyl-3,4-diphenyl-4,5-dihydro-isoxazole-5-alcohol and further studying 3-methyl-4,5-diphenyl-4,5-dihydro-isoxazole-5-alcohol in the aspects of preparation process, detection process and purification process, important quality monitoring significance is provided for the process with the 5-methyl-3,4-diphenyl-4,5-dihydro-isoxazole-5-alcohol as an industrial production raw material.

Easily available nickel complexes as catalysts for the intermolecular hydroamination of alkenes and alkynes

A series of nickel complexes of the type [(P-P)NiX2] ((P-P) = bisphospines or bisphosphites, X = chloride, triflate) were used as catalysts for the hydroamination of both activated and unactivated alkenes and alkynes with pyrrolidine. In general, the use of activated unsaturations, such as acrylonitrile, required mild reaction conditions (e.g. 100 °C and 4 h) in comparison with other non-activated alkenes. Particularly with a series of alkynes, the use of nickel(ii) centers diminished or even inhibited the formation of otherwise undesired homocoupling and/or transfer hydrogenation by-products, such as the ones obtained in the presence of zerovalent nickel. When using less activated substrates, better selectivity was obtained, although harsher reaction conditions were needed. From a general perspective, the results of this report strongly support the potential use of nickel as a good candidate for further application in the hydroamination of organic unsaturations by means of screening of several π acceptor ligands. The Royal Society of Chemistry.

NOVEL CATALYSTS

The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions.

Nickel-catalyzed transfer semihydrogenation and hydroamination of aromatic alkynes using amines as hydrogen donors

The transfer hydrogenation of diphenylacetylene to yield cis- and trans-stilbenes was achieved using a variety of amines as hydrogen donors and the complex 1 ([(dippe)Ni(μ-H)]2) in catalytic amounts (0.5% mol). The use of nucleophilic amines such as pyrrolidine in neat conditions afforded the hydroamination of diphenylacetylene, in moderate to high yields. Cyclization of 2-ethynylaniline also was carried out under similar conditions, with 1 in catalytic amounts, but in low yield, mainly due to the formation of homocoupling products of the starting material. The hydrogenation of diphenylacetylene by using other nitrogenated compounds such as aromatic N-heterocycles was addressed to give a metal-mediated process, using 1 in stoichiometric amounts.