42366-72-3 Usage
Uses
Used in Mass Spectrometry-based Proteomics Research:
DIAZALD(R)-N-METHYL-D3 is used as a stable isotope labeling reagent for quantitative proteomics studies. It allows for the accurate quantification and comparison of protein levels in different samples by labeling peptides with heavy isotopes.
Used in Metabolic Flux Analysis:
In metabolic flux analysis, DIAZALD(R)-N-METHYL-D3 serves as a valuable tool for tracing the flow of metabolites through metabolic pathways. Its use in this field contributes to a better understanding of cellular metabolism and the identification of key regulatory steps.
Used in Drug Metabolism Studies:
DIAZALD(R)-N-METHYL-D3 is also employed in drug metabolism studies, where it aids in the identification and quantification of drug metabolites. This application is crucial for assessing drug efficacy, safety, and pharmacokinetics, ultimately contributing to the development of more effective therapeutic agents.
Overall, DIAZALD(R)-N-METHYL-D3 plays a significant role in various scientific research areas, particularly in the fields of proteomics, metabolic flux analysis, and drug metabolism studies, by providing a reliable and sensitive method for mass spectrometry-based analyses.
Check Digit Verification of cas no
The CAS Registry Mumber 42366-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,3,6 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 42366-72:
(7*4)+(6*2)+(5*3)+(4*6)+(3*6)+(2*7)+(1*2)=113
113 % 10 = 3
So 42366-72-3 is a valid CAS Registry Number.
42366-72-3Relevant academic research and scientific papers
Efficient, scalable and economical preparation of tris(deuterium)- and 13C-labelled N-methyl-N-nitroso-p-toluenesulfonamide (Diazald) and their conversion to labelled diazomethane
Shields, Samuel W.J.,Manthorpe, Jeffrey M.
, p. 674 - 679 (2015/01/16)
A method for the preparation of multi-gramme quantities of N-methyl-d3-N-nitroso-p-toluenesulfonamide (Diazald-d3) and N-methyl-13C-N-nitroso-p-toluenesulfonamide (Diazald-13C) and their conversion to diazomethane-d2 and diazomethane-13C, respectively, is presented. This approach uses robust and reliable chemistry, and critically, employs readily commercially available and inexpensivemethanol as the label source. Several reactions of labelled diazomethane are also reported, including alkene cyclopropanation, phenolmethylation and α-diazoketone formation, as well as deuteriumscrambling in the preparation of diazomethane-d2 and subsequent methyl esterification of benzoic acid.
