42366-72-3 Usage
General Description
Diazald?-N-Methyl-D3 is a stable isotope labeling reagent used for high-resolution mass spectrometry applications. DIAZALD(R)-N-METHYL-D3 is a deuterated derivative of N-methyl diazald? which is widely utilized in mass spectrometry-based proteomics research. The deuterium-labeled version, Diazald?-N-Methyl-D3, can be used for quantitative proteomics studies by labeling peptides with heavy isotopes to accurately quantify and compare protein levels in different samples. Additionally, it can also be used in metabolic flux analysis and drug metabolism studies, offering improved sensitivity and accuracy in mass spectrometry analyses.
Check Digit Verification of cas no
The CAS Registry Mumber 42366-72-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,3,6 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 42366-72:
(7*4)+(6*2)+(5*3)+(4*6)+(3*6)+(2*7)+(1*2)=113
113 % 10 = 3
So 42366-72-3 is a valid CAS Registry Number.
42366-72-3Relevant articles and documents
Efficient, scalable and economical preparation of tris(deuterium)- and 13C-labelled N-methyl-N-nitroso-p-toluenesulfonamide (Diazald) and their conversion to labelled diazomethane
Shields, Samuel W.J.,Manthorpe, Jeffrey M.
, p. 674 - 679 (2015/01/16)
A method for the preparation of multi-gramme quantities of N-methyl-d3-N-nitroso-p-toluenesulfonamide (Diazald-d3) and N-methyl-13C-N-nitroso-p-toluenesulfonamide (Diazald-13C) and their conversion to diazomethane-d2 and diazomethane-13C, respectively, is presented. This approach uses robust and reliable chemistry, and critically, employs readily commercially available and inexpensivemethanol as the label source. Several reactions of labelled diazomethane are also reported, including alkene cyclopropanation, phenolmethylation and α-diazoketone formation, as well as deuteriumscrambling in the preparation of diazomethane-d2 and subsequent methyl esterification of benzoic acid.
