42407-05-6

Upstream product

• 781-86-2 2,2-dimethyl-1-(4-nitrobenzoyl)aziridine 
• 13793-40-3 2-Methyl-2-(4-nitrobenzamido)-propanol 
• 555-16-8 4-nitrobenzaldehdye 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 62-23-7 4-nitro-benzoic acid 
• 67-64-1 acetone 
• 619-72-7 4-nitrobenzonitrile 
• 98-59-9 p-toluenesulfonyl chloride 
• 1613-78-1 N-hydroxy-N-(1,1-dimethylethyl)-4-nitrobenzamide 
• 4231-71-4 1H-1,2,3-benzotriazol-1-yl-4-nitrophenylmethanone 

Downstream Products

• 69876-88-6 2-(4-aminophenyl)-4,4-dimethyl-2-oxazoline 
• 1322669-58-8 C₂₀H₁₈ClN₃O 
• 42449-42-3 dichloro-[3-dichloroacetyl-4,4-dimethyl-2-(4-nitro-phenyl)-oxazolidin-2-yl]-acetic acid methyl ester 
• 42449-40-1 8,8-dichloro-5-dichloromethylene-3,3-dimethyl-8a-(4-nitro-phenyl)-tetrahydro-oxazolo[3,2-c][1,3]oxazin-7-one 

Relevant academic research and scientific papers

Silicon-rhodamine isothiocyanate for fluorescent labelling

An efficient synthesis for silicon-rhodamines was developed, enabling the preparation and evaluation of silicon-rhodamine isothiocyanate (SITC) as a novel tool for facile fluorescent labeling. Ease of use in conjugation to amino groups, high stability and excellent photophysical properties are demonstrated. SITC-actin was found to be neutral to F-actin polymerization induction and well suited for high resolution fluorescence microscopy.

Aerobic C(sp2)-H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores

The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl·LiCl and subsequent oxidation with molecular oxygen or air as a green oxidant is reported. This method proceeds under mild conditions at room temperature with high regioselectivity and chemoselectivity. The obtained phenols exhibit tunable luminescence properties, induced by excited-state intramolecular proton transfer. This method opens a new opportunity for the sustainable synthesis of luminescent organic molecules.

Facile Syntheses of Oxazolines and Thiazolines with N-Acylbenzotriazoles under Microwave Irradiation

Microwave reactions of 2-amino-2-methyl-1-propanol (2) or 2-aminoethanethiol hydrochloride (4) with readily available N-acylbenzotriazoles 1a-j in the presence of SOCl2 produced 2-substituted 2-oxazolines 3a-j in 84-98% yields and 2-substituted

Pd(OAc)2/2-aryl-2-oxazolines catalyzed Suzuki coupling reactions of aryl bromides and arylboronic acids

A series of 2-aryl-2-oxazolines were prepared and examined as ligands for the Suzuki coupling reaction of aryl bromides and arylboronic acids. 2,2′-(1,3-Phenylene)bisoxazoline/Pd(OAc)2 was found to be an efficient catalyst for a variety of substrates to afford the coupling products in good to excellent yields.

Natural Kaolinitic clay catalyzed conversion of nitriles to 2-oxazolines

Natural Kaolinitic clay has been found effective as catalyst in the conversion of aromatic and aliphatic nilriles with 1,2-aminoalcohol to 2-oxazolines (56-96%, yield).

A facile one stage synthesis of oxazolines under microwave irradiation

A rapid, high yielding procedure for the synthesis of 2-substituted oxazolines has been achieved under microwave irradiation from alkyl and aryl nitriles and β-amino alcohols using a mild Lewis acid catalyst.

A MILD PROCEDURE FOR THE PREPARATION OF 2-OXAZOLINES

A general procedure using triphenylphosphine and diethylazodicarboxylate to prepare 2-oxazolines is described.